To Evaluate the Effectiveness of Omeprazole Associated With Calcium Hydroxide and Erythromycin as an Intra Canal Medicament - An Invivo Study on Rats.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Background : Proton pump inhibitors are used in combination with calcium hydroxide as an intracanal medicament for elimination of enterococcus faecalis. The aim of this invivo study on wistner rats was to evaluate the efficacy of association of omeprazole with calcium hydroxide and erythromycin as intra canal medicament in rats induced with periapical lesions. Materials and Methods : Periapical lesions were induced on incisor teeth of 30 male Wistner rats. After 28 days, root canal of each tooth was prepared, filled with intra canal medicaments and divided into three groups. Group 1 - Calcium hydroxide + PEG, Group 2 - Calcium Hydroxide + Omeprazole + PEG, Group 3 - Calcium Hydroxide + Omeprazole + Erythromycin + PEG, and access cavity was sealed with cavit for 15days. Microbiological samples were taken in 2 periods. S1- after 28 days of access cavity preparation, S2 -15 days after placement of intracanal medicaments. Results: Microbiological Analysis revealed significant decrease of colony forming units from S1 to S2 time periods in all the 3 groups. Conclusion: Results showed that association of Omeprazole with Calcium Hydroxide and Erythromycin favoured superior Antibacterial Efficacy against Enterococcus faecalis in comparison with Calcium hydroxide and Calcium hydroxide used in combination with Omeprazole.
Authors and Affiliations
Dr Edulapalli Keerthi
Keywords
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