To Study A Formulation, Development And Optimization Of Lornoxicam 8mg Tablets
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Tablet dosage form constitutes a major portion of the drug delivery systems that are currently available. These are usually prepared with the aid of suitable pharmaceutical excipients. They may vary in appearance, size, shape, weight, hardness, thickness, disintegration and dissolution characteristics and in other aspects depending on their intended use and method of manufacturing. Tablets are manufactured primarily by either granulation or direct compression. The latter involves the compression of a dry blend of powders that comprises drugs and various excipients. The simplicity and cost effectiveness of the direct compression have positioned direct compression as an attractive alternative to traditional granulation technologies. Fast disintegrating (DT) dosage form provides an opportunity to manufacturers to extend product life cycle and to expand market. Fast disintegrating tablets have this opportunity over conventional tablets. Lornoxicam is non steroidal anti-inflammatory drug (NSAID) and used in treatment of post traumatic pains (PTP), muscular and skeletal pains, joint disorder and rheumatic arthritis (RA). Fast onset of action is required in these indications and to improve bioavailability as well. Lornoxicam fast disintegration tablets were prepared by direct compression method by using Low substitute hydroxypropylcellulose (HPC) as disintegrating agent and optimized sodium bicarbonate and calcium hydrogen phosphate, anhydrous. Independent variables were concentration of excipients used in the formulation while dependent variables were disintegration time and percent drug released. Optimized formulation, T-06, showed drug content (100.527%), disintegration time (40sec), percent drug released (102.179%). Present study demonstrated potential for rapid absorption, improved bioavailability, effective therapy and patient compliance.
Authors and Affiliations
I. Rahman1, W. Jamil2, A. Zahid, K. Farooqi4
Keywords
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