To Study the Clinical Profile of Tuberculosis in HIV Positive Patients and Impact of Antitubercular Therapy
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 2
Abstract
Background: There is paucity of data from peripheral centres on clinical profile of Tuberculosis in HIV positive patients and outcome of those patients to chemotherapy. Methods: An observational study of HIV TB co infected patients compared to patints suffering from Tuberculosis alone. Results: Most of the patients having TB/ HIV co infection as well as TB without HIV are males belong to the age group of 21 to 60.Most of TB/HIV coinfected patients are drivers and labourers belonged to low socioeconomic group and were illiterate. Common presenting symptoms in the studied patients are fever, cough, appetite loss and weight loss. Most common route of transmission of HIV infection was found to be from sexual route. Most of patients have history of exposure to commercial sex worker. Extra pulmonary tuberculosis was seen in significant number TB patients co infected with HIV. Most of the TB/HIV co infected patients were found to sputum negative atypical radiological presentation was seen in significant number. Common complications seen in TB/HIV co infected patients was Gastrointestinal side effects and hepatotoxicity. Outcome (favourable) in HIV positive tuberculosis was found to be almost similar to HIV negative tuberculosis patients. In TB/HIV co infected patient better outcome with higher CD4 count was seen. In TB/HIV co infected patients sputum negativity was found to have higher favourable outcome (76%) as compared to sputum positive HIV patients (36%). Conclusion: HIV tb coinfection is more common in sexually active age group and commonest mode being heterosexual transfer. Extra pulmonary TB is common among HIV co infected patients with better treatment outcome with higher CD4 count, sputum negativity.
Authors and Affiliations
Dr Abhijit Pal
Keywords
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