To Study the Effect of Intravenous Clonidine on Attenuation of Hemodynamic Stress Response of Laryngoscopy and Intubation in Surgeries under General Anaesthesia
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 12
Abstract
Abstract: Endotracheal intubation is always associated with certain hazards. Few common complications are trauma during laryngoscopy, airway obstruction by kinking or malposition of tube, trauma to vocal cords leading to oedema and postoperative horseness and ulceration are not uncommon. Besides these, there are certain cardiovascular disturbances, which often go unnoticed due to lack of proper monitoring cardiac disturbances may be transient and may not lead to deleterious effects in normal healthy individuals but can lead to serious consequences in patient with cardiovascular diseases. Various methods are used to attenuate this hemodynamic response. In present study, we have used i.v. clonidine just before induction of anaesthesia to attenuate this reflex response. This randomized control study was conducted on 60 patients of ASA grade 1 and 2 after taking ethics committee approval. Patients were divided into two groups. In Group 1 (n=30), patients received i.v. clonidine just before induction of anaesthesia and Group 2 (n=30), patients received Placebo. Diastolic, systolic and mean blood pressure and heart rate were measured throughout the procedure and recorded for five minutes just after the intubation. i.v. clonidine given pre-emptively helps attenuating adverse hemodynamic response occurring due to laryngoscopy (p<0.05) in comparison to control group. i.v. clonidine given pre-emptively reduces adverse hemodynamic response occurring due to laryngoscopy.
Authors and Affiliations
Ritu Masar, Anju Gautam, Rajan Godwin, Sachin Gajbhiye
Keywords
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