To Study The Effect of L-Arginine in Oligohydramnios To Improve Perinatal Outcome
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background: Oligohydramnios is a common diagnosis in obstetrics and carries an increased risk of operative interference and perinatal mortality and morbidity. Administration of L-arginine (precursor of nitric oxide) has been suggested to improve amniotic fluid index (AFI) in Oligohydramnios. Objective: To study the effect of L-Arginine in improving AFI and Perinatal outcomes in Oligohydramnios Methods: A Retrospective study was conducted at Pacific Medical College And Hospital,Udaipur consisting of 50 antenatal patients with decreaesd liqour [AFI<8 cm] remote from term. Patients started on L-arginine sachets (3 g, 3 sachets a day) after evaluation of risk factors. The treatment was continued till improvement in liquor was noted. However, patients were considered for delivery if the AFI remained<5cm. Further, mean increase in AFI, intervention delivery interval, and neonatal outcome were studied . Results: The mean gestational age at the time of recruitment was 32.4 weeks. The mean AFI noted was 5.321cm.These patients were delivered at 35 ± 1.1 weeks, and thus ,pregnancy could be prolonged by 2.3 ± 1.1 weeks. The mean AFI at the end of therapeutic intervention was 8.553,and thus, an AFI increase of 3.232 cm could be obtained.There was no significant neonatal morbidity in these patients. Significant improvement in liquor volume was obtained in these patients after intervention with L-arginine sachets. Conclusion: L-arginine supplementation is promising in improving volume of amniotic fluid in cases of oligohydramnios and prolonging pregnancy by a mean of 2.3weeks, allowing fetal lung maturation thus benefiting the neonatal outcome.
Authors and Affiliations
Dr. Archana Sharma, Dr. Sanchita Dashora, Dr. Rajrani Sharma, Dr. Kanika Chandra, Dr. Maheshwar Singh Gunawat
Keywords
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- EP ID EP593818
- DOI 10.9790/0853-1604041619.
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