TO STUDY THE THERAPEUTIC RESPONSE FOLLOWING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 62
Abstract
BACKGROUND Acquired Immunodeficiency Syndrome (AIDS) is an infectious disease caused by Human Immune Deficiency Virus (HIV). It affects all the organ systems in the human body and has been studied so extensively in a short period worldwide. Highly Active Antiretroviral Therapy (HAART) for treatment of HIV infection has improved steadily, and more recently new drugs have been approved, offering dosing convenience and improved safety profiles. HIV infection is more prevalent in the active reproductive age group of 20–50 years especially in employed migrant youths, drivers, constructional workers and married couples with male predominance. Aim- To study the Clinical stage response, Immunological response and Functional status improvement to Highly Active Antiretroviral Therapy. MATERIALS AND METHODS This study was conducted in 100 People Living With HIV & AIDS (PLWHA) more than 20 years of age only after thorough history, clinical and systemic examination who have attended the General Medicine OPs, Wards and ART centre, Mahatma Gandhi Memorial Government (Tertiary Care) Hospital, Tiruchirapalli, Tamilnadu, India. RESULTS Our study showed high prevalence of HIV among 20-50 years of active reproductive age group especially in employed migrant youths, drivers, constructional workers, married couples with male predominance. The incidence of TB was more common in PLWHA with CD4 count less than 200/μL. After appropriate Antituberculosis Treatment (ATT) and HAART, there was significant improvement in clinical stages, functional, mean CD4 counts, and immunological success around 97% in this study. CONCLUSION Initiation of HAART was associated with increase in body weight, immunological response, functional status, mental wellbeing and decrease in occurrence of opportunistic infections (OI). PLWHA without OI have good clinical stage improvement than with OI. Opportunistic infections are more common in bedridden category (88%) than working category (66.7%). CD4 count response following HAART was more in working category than the bedridden category.
Authors and Affiliations
Alagamuthu Veni, Sappani Kasipandian, Natesan Kathirvel Senthilnathan
Keywords
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- EP ID EP230561
- DOI 10.14260/Jemds/2017/985
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