TO STUDY THE USE OF HYDROXYCHLOROQUINE IN SMALL DOSES IN REGRESSION OF DIABETIC NEPHROPATHY IN PATIENTS OF TYPE II DIABETES MELLITUS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 3
Abstract
BACKGROUND The outcomes with the armamentarium of drugs targeting the progression of Nephropathy in Type II Diabetic patients are not promising with most of the patients needing haemodialysis ultimately. Hydroxychloroquine (HCQS), an anti-malarial used mainly for treatment in Rheumatoid arthritis, Psoriasis and Lupus nephritis had been recently approved by Drug Controller General of India, in 2015, as an anti-Diabetic drug. With recent studies, HCQS was found to decrease proteinuria and retarded the progression of nephropathy in Lupus nephritis patients. In few of the studies, Hydroxychloroquine also proved to have favourable effects on Lipid profile of subjects. We decided to investigate Hydroxychloroquine in Diabetic Nephropathy patients, proposing that it could retard the progression of Nephropathy in Type II Diabetics, just as it proved beneficial and disease modifying in Lupus Nephritis patients. MATERIALS AND METHODS This study was non-randomised controlled trial. A total of 67 patients with Type II Diabetes Mellitus (in the age group of 30 - 80 yrs. with clinical evidence of Diabetic Kidney Disease [DKD], HbA1c ≥ 6.5) were selected among admitted patients of the KPS PG Institute of Medicine at LLR and Associated Hospital, GSVM Medical College, Kanpur and alternatively divided into two groups with one group taking Hydroxychloroquine (100 mg b.i.d.) in addition to their regular medications. Both groups were then looked for any significant changes in their renal function after 3 months. RESULTS In our study with S. creatinine there was decline of 19.99% from baseline T0 to T3 in Hydroxychloroquine group, while it increased from T0 to T3 in Non-Hydroxychloroquine group by around 27.56%, both of which were significant (P<.001). Similarly, eGFR was found to be rising by 27.9% in the Hydroxychloroquine group and decreased by 25.11% in the Non-Hydroxychloroquine group, again which was statistically significant (P<.001). Also, Urinary ACR decreased by 26.59% in the Hydroxychloroquine group, but continued to increase by 19.63% in the Non-Hydroxychloroquine group, both of which were statistically significant (P<.001). CONCLUSION While eGFR progressively declined in the Non-Hydroxychloroquine group, an improvement in eGFR was observed in the Hydroxychloroquine group. Therefore, we concluded that HCQS can be an option in patients of early stages of DKD for regression of Diabetic Nephropathy.
Authors and Affiliations
Jitendra Singh Kushwaha, Shri Krishna Gautam, Harshit Khare
Keywords
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- EP ID EP284686
- DOI 10.14260/jemds/2018/77
- Views 75
- Downloads 0
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