Tobacco plant: A possible key to Ebola vaccine
Journal Title: Journal of Coastal Life Medicine - Year 2017, Vol 5, Issue 5
Abstract
In 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Approximately 30 years after the first epidemic, there is no vaccine or therapeutic medication approved to counter the Ebola virus. In this review, it emphasized that plant based antibodies can be an effective cure to Ebola hemorrhagic fever. Genetically modified Nicotiana benthamiana is used to manufacture ZMapp drug by Kentucky BioProcessing. ZMapp three-antibody cocktail binds to the Ebola virus to deactivate it and provides simulated immune response against sugar-tagged proteins on the outside of the Ebola virus, which had verified efficacy against Ebola infection in nonhuman primates and also successfully treated two American medical workers infected with Ebola virus disease.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP236171
- DOI 10.12980/jclm.5.2017J7-9
- Views 107
- Downloads 0
Toxicity of cadmium on larvae of Palaemon adspersus Rathke, 1837 from the Black Sea
Objective: To evaluate the suitability of Palaemon adspersus (P. adspersus) as a bio-indicator for 4 and 10 days of cadmium toxicity bioassays. Methods: Four and ten days experiments were designed. CdCl2·2½H2O was dissol...
The potential utility of nested PCR for investigation of Coxiella burnetii in Iranian snails
Objective: To detect the prevalence of Coxiella burnetii (C. burnetii) in two species of snails consisted of Lymnaea palustris (L. palustris) and Pomacea canaliculata (P. canaliculata) by using nested PCR method in Chaha...
Isolation and characterization of endosulfan-degrading bacteria from contaminated agriculture soils
Objective: To isolate and characterize endosulfan-degrading bacteria from Kerman pistachio orchards. Methods: Endosulfan-degrading bacteria were enriched in Bushnell-Hass medium. Identification and sequencing of prevalen...
GC-MS and FT-IR analysis of a coastal medicinal plant-Hyptis suaveolens (L.) Poit
Objective: To investigate the bioactive components of a coastal medicinal plant, Hyptis suaveolens (L.) Poit. (H. suaveolens) leaves using fourier transform-infrared spectroscopy and gas chromatography-mass spectrometer...
The role of probiotics in the control of bacterial diseases and biodegradation of organic matter in shrimp (Penaeus vannamei) culture ponds of South India
Objective: To utilize bacterial consortium as probiotics for the biodegradation of organic matter and to control the emergence of bacterial disease in shrimp culture pond. Methods: Water samples were collected from shrim...