Total proteins, albumin and HBA1c in type 2 diabetes mellitus

Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 3, Issue 3

Abstract

Type 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance [affecting carbohydrate, lipid and protein metabolism]. Glycation of proteins, including hemoglobin and albumin have been implicated in comp diabetes. The aim of the present study was to evaluate the association between variations in the levels of albumin and total proteins with glycated hemoglobin [HbA1c]. Present study involved 408 participants who visited Owaisi Hospital and Research Center, Hyderabad from November 2015 to June 2017. 204 were freshly detected diabetic patients and 204, age and sex matched healthy controls. Fasting blood glucose levels, HbA1c, plasma total proteins and plasma albumin were estimated. The objective diagnosed cases of Type 2 Diabetes Mellitus. HbA1c levels increased (p<0.001) from 4.90 ± 0.53 in controls to 9.02 ± 2.06 in cases, plasma albumin levels were decreased (P<0. plasma total protein levels were increased from 6.8±0.81 in controls to 7.31±0.93 [p< 0.0013*] in cases. Globulin levels increased (P<0.50) from 1. 68 ± 0.29 in controls to 1.74 ± 0.57 in cases. 0.43 in controls to 1.84± 0.36 in cases. Glycation accelerates albumin degradation via increasing catabolic rate and decreasing protein half-life, and competes with other proteins for glycation. Our study sho between HbA1c and serum albumin. Freshly detected diabetic patients were associated with increased total proteins and decreased A/G ratio. We observed in our study that albumin levels may be associated inversely with HbA1c values results may lead us to study the ways in which glucose and proteins may interact in a newer approach and could aid in understanding hyperglycemia and its estimation.

Authors and Affiliations

F A Nazki, A Syyeda, S Mohammed

Keywords

Related Articles

25(OH) vitamin D level and severity of chronic liver disease: A controlled study from Eastern India

Background: Chronic Liver Disease (CLD) is defined as long term process of progressive degeneration and regeneration of liver cells and with advancement, leads to hepatic fibrosis, scarring, and cirrhosis. 25(OH) Vitamin...

Ischaemia modified albumin levels in hyperthyroidism

Background: Hyperthyroidism is characterised by increased levels of thyroid hormones leading to hypermetabolic state. More common in females than males with sex ratio of up to 5:1. Thyroid hormone functions as a stimulus...

Biochemical parameters and its association with quality of life in patients with diabetic foot ulcers

Background: Diabetic foot ulcer (DFU) is a serious complication of Diabetes mellitus (DM) with significant impact on the quality of life(QoL). Various biochemical parameters can play important role in evaluating QoL in D...

Correlation of serum calcium, phosphorus and alkaline phosphatase levels with eGFR in newly diagnosed chronic kidney disease patients

Background: Chronic kidney disease or chronic renal failure is a health problem affecting mainly the elderly population. Chronic kidney disease (CKD) leads to many serious and life threatening complications like dyslipid...

Assessment of hypothyroidism among Type II DM patients attending in a rural teaching hospital, Sangareddy

Background: The present study was undertaken to assess the interdependent relationship between type 2 DM and hypothyroidism among Type 2 diabetic patients attending a teaching hospital. Materials and methods: In the pres...

Download PDF file
  • EP ID EP258562
  • DOI -
  • Views 285
  • Downloads 0

How To Cite

F A Nazki, A Syyeda, S Mohammed (2017). Total proteins, albumin and HBA1c in type 2 diabetes mellitus. Medpulse International Journal of Biochemistry, 3(3), 40-42. https://europub.co.uk./articles/-A-258562