Toxic Effects of Aqueous Extract of Plectranthus amboinicus (Lour) Spreng on Allium cepa
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 10, Issue 3
Abstract
Aims: Plectranthus amboinicus (Lour) Spreng. belonging to the Lamiaceae family being extensively used in folk medicine for its anti-inflammatory effects, nonetheless, there is a lack of more substantial data on the toxicogenetic effects of this preparations. This study aimed to evaluate possible cytotoxic effects of aqueous extract of leaves of Plectranthus amboinicus on Allium cepa assay. Methods: Distilled water was used as negative control and a solution of copper sulfate was used as positive control. Also a qualitative chemical screening for the identification of the major classes of active constituents were performed. Results: The results demonstrate the presence of diterpenes and flavonoids, and a decreased in the mitotic index as the concentrations of extract increased. Conclusions: These findings suggest that a toxic effect at high doses of Plectranthus amboinicus can be related to the presence of flavonoids and diterpenes.
Authors and Affiliations
Cláudia Fernanda Caland Brígido, Márcia Fernanda Correia Jardim Paz, Marcus Vinícius Oliveira Barros de Alencar, Antônio Luiz Gomes Júnior, Alexandre de Barros Falcão Ferraz, Ivana Grivicich, Ana Amélia de Carvalho Melo Cavalcante, Jaqueline Nascimento Picada
Keywords
Related Articles
- EP ID EP342340
- DOI 10.9734/BJPR/2016/23990
- Views 101
- Downloads 0
The Effects of Massage on Oxygen Saturation of Infants with Respiratory Distress Syndrome Treated with Nasal Continuous Positive Airway Pressure
Background: The aim of this study was to assess the effect of massage on oxygen saturation of infants with respiratory distress syndrome (tactile and kinesthetic stimulation). These infants have immature systems to coope...
In vitro Antimicrobial Activity of Fruit Pulp Extracts of Azanza garckeana (F. Hoffm.) Exell & Hillc. and Isolation of One of its Active Principles, Betulinic Acid
Aims: To perform anti-microbial activity guided isolation and to characterize compound(s) from fruit pulp (extracts) of Azanza garckeana. Place and Duration of Study: Department of chemistry, University of Agriculture,...
Drug Prescribing Pattern among Physicians in an Outpatient Department of Tertiary Hospital, KSA
The Aim: Was to assess the current prescribing pattern in the outpatient settings of tertiary hospital in Saudi Arabia, using WHO core drug use indicators as a measurement tools. Methods: A retrospective study was desig...
Identification of n-Hexane Fraction Constituents of Archidium ohioense (Schimp. ex Mull) Extract Using GC-MS Technique
Aims: To screen for the presence of bioactive phytoconstituents in hexane fraction of Archidium ohioense using the GC-MS technique. Study Design: Phytochemical screening via GC-MS technique. Place and Duration of Study...
Antimalarial Activity of Root Bark Extract and Fractions of Callichilia stenopetala Stapf (Apocynaceae) against Plasmodium berghei in Mice
Introduction: Malaria is a life threatening disease caused by infection of red cells by Plasmodium parasites and is very prevalent due to emergence of resistance to the parasites. The plant Callichilia stenopetala Stapf...