Toxicity Evaluation of a Traditional Polyherbal Unani Formulation Jawarish Shahi in Rats
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 5
Abstract
Jawarish Shahi (JS) is a compound polyherbal Unani pharmacopoeial formulation indicated for Khafqan (Palpitation), Nafkh-e-Shikam (Flatulence) and Waswas (Insanity; false perception and hallucinations). Jawarish Shahi contains herbs like Halela (Terminalia chebula), Amla (Emblica officinalis), Kishneez (Coriandrum sativum), Elaichi Khurd, (Elettaria cardamomum), and Bed Mushk (Salix caprea). The present study was carried out as per OECD 408 guidance to evaluate 90 days repeated oral dose toxicity in male and female Sprague Dawley rats. The study was performed at dose levels 1028 and 2000 mg/kg bw. No adverse effects were reported with respect to body weight, feed intake, behavior and clinical signs indicative of systemic toxicity. The expected growth pattern was observed in body weight and feed intake as compared to control group at both dose levels in male and female rats. There were few significant alterations with respect to hematology, and clinical biochemistry, however the results were within normal range thus considered toxicologically insignificant. The microscopic examination of different organ/tissue showed that no histopathological changes were observed. The findings of the study showed that No Observed Adverse Effect Level (NOAEL) for JS is greater than 2000 mg/kg body weight.
Authors and Affiliations
Mohd Urooj, Mohammad Ahmed Khan, G. Thejaswini, Munawwar Husain Kazmi, Gulam Mohammed Husain
Keywords
Related Articles
- EP ID EP49837
- DOI -
- Views 161
- Downloads 0
Inhibition of Dehydrogenase Activity in Pathogenic Bacteria Isolates by Aqueous Extract of Curcuma Longa (Turmeric) Rhizome
Inhibition of dehydrogenase activity in pathogenic Gram – positive and Gram – negative microorganism exposed to ethanol extract of curcuma longa was used as an index for assessment of its antibacterial activity. Assay o...
Preliminary Phytochemical Analysis of Bark Extract of Ficus Infectoria Plant
There is Pakad (Ficus infectoria), is a large tree in Moraceae family, traditionally used in treatment of several diseases (diabetes, menstrual disorders, washing ulcers, leucorrhoea, erysipelas, epitaxis antibacterial...
Evaluation of Salvia haematodes Linn for their antioxidant, anti-microbial, anti-lipoxygenase and anticholinesterase activity
The indigenous medicinal plant Salvia haematodes Linn (SAL) was screened for its pharmacological activities. The crude extract fractions were prepared in methanol, n-hexane, di chloromethane (DCM) and n-butanol by cold...
Emodin, isolated and characterized from an endophytic fungus Polyporales sp., induces apoptotic cell death in human lung cancer cells through the loss of mitochondrial membrane potential
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a Chinese herbal anthraquinone that exhibits numerous biological activities, such as antitumor, antibacterial, antiinflammatory, and immunosuppressive. From an endophy...
Natural dyeing of fabrics using Quercus robur L. (fruit cups) dye and Punica granatum L. (peel) mordant
Investigation was carried out to study the dyeing quality of Quercus robur L. (fruit cups) and Punica granatum L. (peel) mordant for the dyeing of wool and cotton fabrics. The fabrics were dyed both excluding and inclu...