Toxicological and Biochemical Studies of Myristica fragrans Hydroalcoholic Extracts in Albino Rats
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 6, Issue 3
Abstract
Aims: Myristica fragrans is one of the plants used as a herbal medicine. This plant includes some components that can treat many diseases. This study was done to evaluate the M. fragrans hydroalcoholic effects on some hematological parameters, thyroid hormones, some liver enzymes, blood urea nitrogen (BUN) and serum creatinine. Study Design: This study was done on ninety adult male Wistar rats weighing approximately 200 to 220 g. Place and Duration of Study: Nutmeg was authenticated in the Agriculture Faculty of Shiraz University (Shiras is a city in Fars province in the south -West of Iran). This study has been done in department of clinical sciences of faculty of Veterinary Medicine in Kazerun (Farsprovince, Iran) branch of Islamic Azad University, between March and September 2013. Methodology: The Myristica fragrans hydroalcoholic extracts were administrated orally at 4 different doses (100, 200, 400 and 500 mg/kg BW /day) and in two terms (14 and 28 days) in experimental groups (groups A1, A2,A3, A4, B1, B2, B3 and B4). The control group did not receive extract. The Hemoglobin (Hb) concentration, packed cell volume percentage (PCV%), erythrocyte (RBC) and total leukocyte count (WBC), iron, total iron binding capacity (TIBC), ferritin, some liver enzymes, thyroid hormones, BUN and serum creatinine were assayed and compared to control group. Results: The hydroalcoholic extract of M. fragrans have significantly increased effects on erythropoiesis and thrombopoiesis in the long-term and have significantly increased on T4 concentration in short and long periods (P<0.05) and decreased serum iron and TIBC. This extract did not have any significant effects on ferritin, and WBC, in short and long term (P>0.05). Liver enzymes activities, BUN and creatinine concentrations were not increased in any of experimental groups (P>0.05). Conclusion: The hydroalcoholic extract of M. fragrans can be used for anemia, thrombocytopenia and hypothyroidism treatment with safe dosage and term, without any renal and hepatic side effects.
Authors and Affiliations
Ameneh Khoshvaghti
Keywords
Related Articles
- EP ID EP350249
- DOI 10.9734/EJMP/2015/8042
- Views 126
- Downloads 0
Qualitative Characterization of Solvent and Cooked Extracts of Tribulus terrestris L. Fruit
Currently there has been an increased attention globally to identify antioxidant compound that are pharmacologically potent and have low or no side effects. As plants are source of natural antioxidants, much concentratio...
Ethno-Medicinal Plants in Sacred Groves in East Godavari District, Andhra Pradesh, India
Aims: An ethnobotanical study was conducted to document traditional medicinal plants used by indigenous people around the four sacred groves (protected forest patches) of East Godavari district, Andhra Pradesh, India. Pl...
Antibacterial Activity of Methanolic Extracts of Euphorbia heterophylla and Tithonia diversifolia against Some Microorganisms
Aims: To determine the antibacterial activities of methanolic extracts of Euphorbia heterophylla and Tithonia diversifolia on clinical isolates. Place and Duration of Study: The study was carried out at Afe Babalola Uni...
Effect of Aqueous Extract of Cassia alata Linn. on Oral Glucose Tolerance Test in Normal and STZ Induced Diabetic Mice
Aims: To check the effect of the aqueous extract of an antidiabetic plant Cassia alata Linn. on Oral Glucose Tolerance Test (OGTT) in glucose induced normal, and diabetic mice and to check if there is any toxic effect of...
A Natural Formulation Increases Brain Resistance to Oxidative Stress
Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initi...