TOXICOLOGICAL TESTING OF BARKS FROM CROTON RHAMNIFOLIOIDES (EUPHORBIACEAE)
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The present study aimed to study the phytochemical screening of stem bark of C. rhamnifolioides and evaluate the toxicological potential of Artemia salina.Methods: Barks were subjected to methanol extraction at room temperature and, subsequently, a preliminary phytochemical study was conducted. The methanol extract at concentrations of 500, 250 and 125 mg/ml was investigated in the toxicological study through the A. salina method.Results: The phytochemical screening showed the presence of secondary metabolites: alkaloids, triterpenes and flavonoids. The methanol extract showed a LC50 of 486.59 µg/ml, with a moderate toxicity, in which viable LC50 were 27.5, 82.5 and 100%, respectively.Conclusion: This study may contribute to the knowledge of this species’ toxicity, inform the public on the proper use of herbal and natural medicines and assist in the cataloging of information on plants used in popular medicine.Â
Authors and Affiliations
Izabela Rangel Lima, Ivanise Brito Da Silva, Mardonny Bruno De Oliveira Chagas, Roberta Maria Pereira Leite, Maria Bernadete De Sousa Maia, SÔnia Pereira Leite
Keywords
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