Tranexamic Acid: Role in Prevention of Postpartum Hemorrhage
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
The objective of the study was to determine the role of Tranexamic acid when administered along with AMTSOL in the prevention of PPH by comparing the blood loss of parturients of Study and Control group. Prospective Randomized Double Blind Control Study. This Study was conducted in the Labour Room, Department of Obstetrics and Gynaecology from August, 2017 to January, 2018 for 6 months. 100 parturients undergoing vaginal delivery were allocated to either study or control by randomization. Tranexamic acid was given during the third stage of labor in Study group in addition to the routine care Active Management of Third Stage of Labour (AMTSOL) whereas the Control group had AMTSOL alone. Blood loss was measured in both groups by Gradient Bag Method from placental delivery to next 2 hours. Volume of blood loss was considered as the outcome variable. Data was analyzed by using student paired t-test with IBM SPSS Statistics Software and p – value was determined. It was observed that there was a mean Blood loss of 141.9 ml in study group compared to 270.4 ml in control group. There was also, a significant reduction in blood loss (p value <0.03). It is concluded from our study that addition of Tranexamic acid along with AMTSOL is an efficient and safe method of reducing blood loss and also the need of blood transfusions. It is also an additional intervention in the prevention of Postpartum hemorrhage (PPH).
Authors and Affiliations
Dr. G. Kesava Chandra, Dr. Shaik Mallika
Keywords
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