Transfusion of a universal platelet product in hematologic patients for emergency
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 11
Abstract
Objective To explore the clinical application of a universal platelet product for emergency, which was prepared by suspending O-type apheresis platelet concentrate in AB-type fresh frozen plasma, so as to improve the platelet support ability in emergency and special treatment. Methods A retrospective analysis of 21 hematological patients, which was divided into 3 groups of platelet transfusion schemes: universal type, AB type and the same type, was performed to analyze the differences in PLT, dose, 24 h PPR, 24 h CCI, follow-up platelet transfusion units and interval, and adverse reactions to transfusion. Results 1)There was no significant difference in PLT, MPV, PDW, K, MA and pH between the initial O-type apheresis platelets and the finished universal platelets (P>0.05). The titers of both anti-A and anti-B in the universal platelets were less than 2. 2) Twenty-one patients were transfused with universal platelet for 27 occasions[1~5 occasions per person; 1 (0.4, 1.0) dose per time]. No adverse reactions to transfusion occurred. 3)There was no significant difference in the effective rate of 24 h CCI and 24 h PPR between the three groups after transfusion(P>0.05). The time interval of the first subsequent platelet transfusion between the compatible group and the universal group was longer than that in the AB-type transfusion group, with significant difference(P<0.05); there was no difference in transfusion dose(P>0.05) among three groups. Conclusion In emergency, the application of this universal platelet product can make hematological patients get timely and effective treatment. Its accessibility and effectiveness can be elevated and the infusion interval can be prolonged by improving the preparation method and storage conditions. This product is not only expected to improve the platelet support capacity for patients with emergency and also those undergoing hematopoietic stem cell transplantation during the blood type conversion period, but also may be a practical method to alleviate the contradiction between platelet supply and demand.
Authors and Affiliations
Li ZHANG, Tao PENG, Xinyu GAN, Hua HE, Jingjing LI, Liping LIU, Yicen PU, Yu QI, Yajuan WU
Keywords
Related Articles
- EP ID EP738405
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.11.010
- Views 40
- Downloads 0
Distribution and transfusion efficacy of unexpected antibody
Objective To investigate the clinical characteristics and antibody distribution as well as evaluate the transfusion efficacy in unexpected antibody positive patients. Methods A total of 12 235 patients from January 1, 20...
Construction and application of Zhejiang provincial rare blood group information sharing system based on data modeling
Objective To establish an information management platform for provincial rare blood group bank to achieve the interconnection and sharing of data such as rare blood group types, donor information and blood inventory, so...
Comparison of the effects of three time series models in predicting the trend of erythrocyte blood demand
[Objective] To analyse and predict the tendencies of using erythrocyte blood in Changsha based on the autoregressive integrated moving average (ARIMA) model, long short-term memory (LSTM) and ARIMA-LSTM combination model...
Amplification efficiency and cost analysis of MP-NAT and ID-NAT in blood samples
Objective To compare the performance and cost-effectiveness between ID-NAT (individual detection of NAT) mode and MP-NAT (mini-pool nucleic acid test) mode in blood screening, and to provide reference for blood sample de...
Changes of coagulation function and other indicators of the thawed FFP and FLP at 2-6℃
Objective To observe the changes of coagulation factor activity and protein content of the thawed fresh frozen plasma (FFP) and fresh liquid plasma (FLP) during storage at 2-6℃, and to provide reference for exploring the...