TRANSGENIC FISH MODEL IN ENVIRONMENTAL TOXICOLOGY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
A number of experiments and the use of drugs have been performed in fish. The fish may be used as model organism in various biological experiments, including environmental toxicology. Aquatic animals are being engineered to increase aquaculture production, for medical and industrial research, and for ornamental reasons. Fish have been found to play an important role in assessing potential risks associated with exposure to toxic substances in aquatic environment. Hence, it has been thought that the development of transgenic fish can enhance the use of fish in environmental toxicology. India has developed experimental transgenics of rohu fish, zebra fish, cat fish and singhi fish. Genes, promoters and vectors of indigenous origin are now available for only two species namely rohu and singhi for engineering growth. Development of fish model carrying identical transgenes to those found in rodents is beneficial and has shown that several aspects of in vivo mutagenesis are similar between the two classes of vertebrates. Fish shows the frequencies of spontaneous mutations similar to rodents and respond to mutagen exposure consistent with known mutagenic mechanisms. The feasibility of in vivo mutation analysis using transgenic fish has been demonstrated and the potential value of transgenic fish as a comparative animal model has been illustrated. Therefore, the transgenic fish can give the significant contribution to study the environmental toxicity in animals as a whole.
Authors and Affiliations
Madhuri Sharma, A. K. Mandloi, Govind Pandey, A. B. Shrivastav
Keywords
Related Articles
- EP ID EP103430
- DOI -
- Views 101
- Downloads 0
PROTECTIVE EFFECT OF PIMPINELLA TIRUPATIENSIS BAL. AND SUBR. AN ENDANGERED MEDICINAL PLANT OF TIRUMALA HILLS AGAINST STREPTOZOTOCIN GENERATED OXIDATIVE STRESS INDUCED DIABETIC RATS
The present study was undertaken to investigate the effect of P. tirupatiensis, extract on antioxidant defense system of liver and pancreas against the streptozotocin-induced diabetic rats. Ethyl acetate extract of P. t...
STUDIES ON MEDICINAL PLANTS OF KORADACHERI VILLAGE, KODAVASAL TALUK, THIRUVARUR DISTRICT, TAMILNADU, INDIA
The present study deals about the availability of medicinal plants in Koradacheri Village, Kodavasal Taluk, Thiruvarur District, Tamil Nadu, India. Evolution of resistance, strains is a major threatening problem. Identif...
ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF FRESH LEAF OF BRASSICA OLERACEAE LINN. VAR. ACEPHALA (D.C) ALEF) (BRASSICACEAE)
Brassica oleraceae (BOL) is the common cabbage and a familiar garden plant, widely used as spice all over the world. Cabbage is an excellent source of Vitamin C and has been widely employed locally to treat acute inflamm...
ANTICANCER ACTIVITY OF PONGAMIA GLABRA V. SEED OIL EXTRACT AGAINST SELECTED HUMAN CANCER CELL LINES
Screening of the seed oil extract from Pongamia glabra V. (Fabaceae) has been carried out for antiproliferative activity of cancer cells. The seed oil was extracted with methanol and then persuasive activity was tested o...
REVELATION OF MECHANISM OF ACTION OF RHIZOPHORA MUCRONATA POIR. BARK EXTRACT FOR ITS ANTIDIABETIC ACTIVITY BY GUT PERFUSION AND SIX SEGMENT METHOD IN LONG EVANS RATS
The aqueous bark extract of Rhizophora mucronata Poir. is used in Bangladesh as a hypoglycemic aid without any knowledge about its probable mode of action . It is an effort to assess the claimed hypoglycemic property of...