Treatment of contact burn injury with hypericum perforatum: An experimental study
Journal Title: Ege Tıp Dergisi - Year 2019, Vol 58, Issue 2
Abstract
Aim: Burns are one of the most difficult physical and psychological traumas that people face. Generally, protection and prevention strategies from burns are practiced. The young and the elderly are most likely to be affected tragically. The aim of the present study is to investigate the effect of Hypericum perforatum methanol extract-containing gel on the healing of burn wounds. Materials and Methods: Forty male rats of the Sprague-Dawley strain were divided into four groups after a 4x4 area of their back was shaved, and an experimental burn was created with the direct contact of an aluminum metal stamp heated in boiling water for 15 seconds. There was no implementation on or treatment of the control group (Group 1). Burn wounds were irrigated with saline solution (Saline group, Group 2), and silver sulphadiazine 1% (Silverdin®) cream (Group 3), Hypericum perforatum methanol extract-containing gel (Group 4), and a placebo gel (Group 5) were applied topically 4 times a day after the contact burn. Histopathological analyses of the burned area were made at 4, 8, and 24 hours. Results: The topical use of Hypericum perforatum methanol extract-containing gel in the experimental contact burns, histologically; resulted in the reduction of collagen discoloration, vascular damage and hair follicle and glandula sebaceous damage while preserving total number of hair follicles, number of vessels and epidermal thickness compared to Silver Sulphadiazine 1% (Silverdin®) cream treatment. Conclusion: Positive effects of topical Hypericum perforatum gel were detected on experimental burns and its use might have beneficial effects on acute burn wounds.
Authors and Affiliations
derya Cabbaroğlu, meltem songür kodik, Yiğit Uyanıkgil, Emel Öykü Çetin Uyanıkgil, Fatih Karabey, Güçlü selahattin Kıyan
Keywords
Related Articles
- EP ID EP603593
- DOI 10.19161/etd.512502
- Views 95
- Downloads 0
Cardiac metastasis of small cell lung cancer diagnosed with PET/CT and echocardiography
Cardiac metastases of malignant tumors occur more frequently than primary tumors of the heart. Local invasion of the pericardium and heart is commonly seen in primary lung cancer, but myocardial metastasis without local...
Dyspnea and elevated liver enzymes following blunt chest trauma
Recently, an increased vehicle use, resulted in icreased in-vehicle traffic accidents at emergency departments. Heart is the another organ that should be kept in mind in frequently encountered blunt chest traumas. Chorda...
Üçüncü trimesterda nadir görülen iniensefali olgusu: Literatür ve yönetim
İniensefali, boynun aşırı hiperekstansiyonu ve çeşitli seviyelerde vertebral defektlerle birlikte görülen nadir ve letal bir anomalidir. Nadiren doğan bebekler ise kısa sürede kaybedilirler. Literatürde çok az sayıda uzu...
Comparison of the biomechanics of plates with modified surface texture in an in vitro chicken model
Aim: Plate and screw combinations have long been in frequent use in the surgical treatment of bone fractures. Developments in the essentials of surgical fracture treatment in the last few years are mainly due to a better...
Bir mevsimsel influenza epidemisi deneyimi
Amaç: Grip, dünyanın bütün bölgelerinde görülebilen, influenza virüsünün neden olduğu bir akut solunum yolu enfeksiyonudur. İnfluenza ile enfekte olan hastalarda, hastaneye yatışı gerektiren ve ölüme yol açabilen komplik...