Treatment strategies in advanced Parkinson’s disease: Review of the literature
Journal Title: Cumhuriyet Medical Journal - Year 2017, Vol 39, Issue 3
Abstract
Parkinson’s disease (PD) is a chronic, neurodegenerative disorder affecting basal ganglia, dopamine-secreting cells in the pars compacta region of the substantia nigra, in particular. It commonly affects people above the age of 50, however younger –onset has also been reported. Since there is an ongoing dopaminergic cell death in basal ganglia, it is a progressive disorder leading to severe disability in the late stages of the disease. The advanced stages of PD are the most challenging part of the disease for clinicians, as well as the patients’ themselves due to the motor fluctuations, freezing of gait, dyskinesia, postural instability, falls, autonomic involvement, non-motor symptoms. This symptomatology corresponds to the stage of 4-5 on the Hoehn and Yahr (H&Y) scale, which is commonly defined as advanced PD. The treatment options in the patients with advanced PD are discussed in this review.
Authors and Affiliations
Yıldız Değirmenci
Keywords
Related Articles
- EP ID EP238904
- DOI 10.7197/223.v39i31705.347447
- Views 103
- Downloads 0
Acinetobacter-associated nosocomial infections in Cumhuriyet University Medical Faculty Research Hospital: Three years’ experience
Objective: Nosocomial infections have high mortality and morbidity. Acinetobacter is a Gram-negative bacilli and an important nosocomial pathogen. The number of nosocomial infections caused by antibiotic resistant-Acinet...
Impact of sociodemographic attributes on high-risk pregnancy
Objective: Identifying the association between sociodemographic data and laboratory parameters, and the complications occurring during the pregnancy monitoring. Method: This study reviewed 127 high-risk pregnant women (H...
Etiology in pediatric patient presented to emergency department with altered state of consciousness: Is it trauma or not?
Consciousness is the state of ability of a person to perceive himself/herself and environment and to give an appropriate response to stimuli. The most frequent causes of childhood consciousness change include electrolyte...
Evaluation of abdominal aortic aneurysm rupture in emergency department: Case report
Abdominal aortic aneurysm (AAA) is a common chronic degenerative disease of the abdominal aorta leading to progressive dilatation, thrombosis, rupture and distal embolization. It is defined as exceed 30 mm or 50% increas...
Domestic violence crimes between 2008-2011 in Turkey
Objective: The purpose of this study; by collecting official data from the Ministry of Justice, analysing trends in time and differences among cities and regions. Method: Criminal data was taken from the criminal courts...