Treatment with Glucagon-Like Peptide-1 Analogues — a Breakthrough in Diabetes Mellitus Type 2 Therapy
Journal Title: Міжнародний ендокринологічний журнал - Year 2014, Vol 4, Issue 60
Abstract
The paper analyzes the data of modern scientific literature on the new class of drugs that restore the effect of glucagon-like peptide-1 (GLP-1). According to modern concepts, the pathophysio-logical mechanisms of therapeutic action of GLP-1 analogues in patients with diabetes mellitus (DM) type 2 primarily due to their bene-ficial effects on β-cell dysfunction, whose role in the pathogenesis of DM type 2 until recently been underestimated. The main targets of GLP-1 are pancreatic islets, where it glucose-dependently stimulates production and secretion of insulin and somatostatin secretion and inhibits glucagon secretion. Furthermore, GLP-1 inhibits β-cell destruction and stimulates their proliferation, increasing their number. The article presents information on the main multicenter studies on analogues of human GLP-1, analyzes hypoglycemic effectiveness of incretins and others of their positive effects.
Authors and Affiliations
V. L. Orlenko, K. P. Zak
Keywords
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