Tumor associated macrophages in breast cancer
Journal Title: Moldovan Medical Journal - Year 2019, Vol 62, Issue 1
Abstract
Background: Cancer research was focused on the studying of proper tumor cells for a long time. Despite the huge progress, there are still a lot of questions, that’s why new molecular markers must be identified. These could reveal new information about tumorigenesis. Material and methods: 15 cases of ductal invasive breast carcinomas have been analyzed and researched on tumor associated macrophages via immunohistochemistry. CD68 was used as a macrophage marker and CD68+ cells were evaluated in tumor nest and peritumoral area, as well as hormone receptors (ER, PR) and HER2 protein. Results: Most of tumors (10 cases out of 15/ 66.7%) were moderately differentiated (G2). The mean and std. error of mean of intratumoral CD68+ cells were 2.0±0.2, of peritumoral CD68+ cells – 1.4±0.2. Intratumoral CD68+ cells registered higher scores than those located in the peritumoral area. Conclusions: CD68+ cells are more likely to be present in the tumor nest rather than in the peritumoral area. This research did not establish any significant correlations between intratumoral and peritumoral CD68+ cells and patients’ age, tumor grade, expression of ER and PR. The content of peritumoral CD68+ cells inversely correlated with the number of HER2+ carcinoma cells.
Authors and Affiliations
Ecaterina Carpenco
Keywords
Related Articles
- EP ID EP585120
- DOI 10.5281/zenodo.2590003
- Views 197
- Downloads 0
Surveillance of antimicrobials use in Emergency Medicine Institute
Background: Antibiotics have had a profound impact on humanity’s health, by improving our ability to prevent, cure and reduce the transmission of many infectious diseases. It is widely known, that the unnecessary or inap...
Osteoarthrosis: possibilities of complex use of the medication Zeel T within the framework of bioregulatory approach
Background: In the article it is considered the essence and possibilities of the bioregulatory approach in the therapy of osteoarthrosis/osteoarthritis (OA) that is realized with the help of the use of complex bioregulat...
Coffee consumption influence upon the clinico-neurophysiological manifestations of primary sleep bruxism
Background: Caffeine is one of the most widely-used psychoactive substances, having multiple stimulating effects. Caffeine is being considered as eliciting a dose-dependent effect on sleep bruxism. Material and methods:...
Evolution peculiarities of the flu in pregnant women
Background: Infection of the pregnant women in advanced period of pregnancy with any of the virus serotypes represents a danger not only for the developing fetus (e.g. fetal intrauterine retardation, fetal distress, olig...
Aqueous humor's biochemical composition in ocular pathologies
Background: Being analogous to a blood surrogate, the aqueous humor has an important role in the regulation of the homeostasis of the ocular tissues. It has many functions: provides nutrition, removes excretory products,...