Tumor Budding in Colorectal Carcinomas.
Journal Title: Turkish Journal of Pathology - Year 2012, Vol 28, Issue 1
Abstract
Objective: In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated. Material and Method: Haematoxylin and eosin stained slides of 73 cases with colorectal carcinoma were retrospectively evaluated for the presence and intensity of tumor budding by 2 observers. After the specimens were assessed, the highest density of tumor budding area was counted in a microscopic field of x200. Cases were separated into 2 groups according to tumor budding density as low grade ( < 10) and high grade (≥10). The relationship of these groups with depth of tumor invasion, histological grade, vascular invasion and lymph node involvement was investigated. Results: Of the 73 colorectal carcinoma cases, 33 (45.2%) had low and 40 (54.8%) had high grade tumor budding density, respectively. There was a statistically significant relationship between high grade tumor budding density and histological grade (p=0.042), lymph node involvement (p=0.0001) and vascular invasion (p=0.0034). Conclusion: High grade tumor budding density is associated with aggressive phenotypical features in colorectal carcinoma.
Authors and Affiliations
Sevda Sert Bektaş, Gülsün Inan Mamak, Ibrahim Metin Cırış, Kemal Kürşat Bozkurt, Nilgün Kapucuoğlu
Keywords
Related Articles
- EP ID EP86292
- DOI 10.5146/tjpath.2012.01099
- Views 77
- Downloads 0
Gastric Strongyloidiasis in a Diabetic Patient
Strongyloidiasis is a common parasitic infection. Gastric location of the parasite is quite rare. Patients at risk are those undergoing immunosuppressive therapy, individuals with malignant hematologic disorders, transpl...
Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
Objective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three b...
Malignant Melanoma Presenting as a Mediastinal Malignant Melanoma Presenting as a Mediastinal Unknown Primary Origin?
The most common site of primary malignant melanoma is the skin, however, virtually any organ system may be involved. Metastatic melanoma of unknown primary origin accounts for approximately 2-6% of all melanoma cases. Th...
Congenital Complete Tracheal Ring in a Neonate: A Case Report
Abnormalities of the upper airway tract lead to congenital high airway obstruction and may complicate neonatal airway management in the delivery room. Congenital complete tracheal rings are a rare and unusual tracheal an...
The Diagnostic and Prognostic Utility of DOG1 Expression on Gastrointestinal Stromal Tumors
Objective: We aimed to review our archives in order to evaluate both the diagnostic and prognostic significance of DOG1 on gastrointestinal stromal tumors (GISTs), and add further insight about those issues to the curren...