Tumor Markers Application for Diagnosis, Monitoring of Recurrence and Prognosis in Esophageal Cancer Patients Treated with Chemotherapy
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Purpose: Tumor Markers Application for Diagnosis, Monitoring of Recurrence and Prognosis in Esophageal Cancer Patients Treated with Chemotherapy. Methods: For the study comprising total 120 cases suffering from esophagus cancer stage I, stage II stage III and Stage IV (before and after different cycle of chemotherapy) were selected. All patients were clinically and histologically diagnosed. A total of 42 age and sex matched healthy subjects taken as control. The circulating levels of GST and CEA activity were assayed in the in the serum of control group and in patients with stomach cancer. Results: Mean GST and CEA activity in serum were significantly higher in stomach cancer patients as compared to control (p<0.001). After chemotherapy (stage II) the activity of GST and CEA were significantly higher than before chemotherapy (stage I). In stage III (after second cycle of chemotherapy) activity was significantly decreased than that of stage II and the activity of GST and CEA was significantly decreased in stage IV (after third cycle of chemotherapy) than stage III (after second cycle of chemotherapy). Conclusion: GST and CEA exhibit highest sensitivity for oesophagus cancer patients. GST measurement in plasma may be useful tumor marker in oesophagus cancer. Alterations in serum GST levels may be helpful to predict the response of chemotherapy. The measurement of GST and CEA may be useful in monitoring of response and prediction and prognosis in patients received chemotherapy. Monitoring of GST is simple, low cost and relatively sensitive screening tool for oesophagus cancer. However the exact role of these findings in clinical practice and their utility in early detection of gastrointestinal cancers still needs further research in depth.
Authors and Affiliations
Suvimal Dutta, Reena Banarjee, Karan Singh Chandrakar
Keywords
Related Articles
- EP ID EP547770
- DOI 10.21276/ijmrp.2017.3.3.004
- Views 99
- Downloads 0
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