Typical and Atypical manifestation of Dengue Fever: A Prospective Observational Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 1
Abstract
Dengue is a major health problem in many parts of India and Jharkhand state has become one of the new endemic areas for dengue. Infection with dengue virus can cause a spectrum of clinical presentation, typical and atypical with altered haematological and coagulation parameters. Aims & Objectives: This study was undertaken to determine the typical and atypical manifestation and haematological profile of patients of dengue admitted in tertiary care teaching hospital in Jharkhand state of India. The study was a hospital based descriptive study with prospective data collection. Material & Methods: One hundred and five patients were admitted with dengue fever as per WHO diagnostic criteria from June to December 2013 Results: Out of 105 cases, 75cases (71.4%) had dengue fever (DF), 27 cases (25.7%) dengue hemorrhagic fever (DF) and three cases (2.8%) had dengue shock syndrome (DSS). Fever and myalgia (100%) were the most common presentation. Among three cases of DSS (2.8 %), one case (0.95%) died of ARDS and one case died of multiorgan dysfunction (0.95%). Malena was the most common bleeding manifestation (44.4%). Low platelet count of less than 100,000/cu mm was present in 47 cases (44.7%) and had poor correlativity to bleeding manifestations. Atypical manifestations included 10 cases (9.5%) of elevated CPK levels&9 cases (8.5%) of elevated LDH levels and an isolated case of hemoglobinuria. Conclusion: Dengue fever has variable manifestations, sometimes puzzling to clinicians and is an important differential of fever in endemic region.
Authors and Affiliations
Rajesh Kumar
Keywords
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