Tyrosine kinase inhibitor –<br /> a new targeted therapy for chronic myeloid leukemia
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2004, Vol 21, Issue 4
Abstract
The treatment of patients with Ph(+) or BCR-ABL(+) chronic myeloid leukemia (CML) did not improve very greatly in the 1990s. It is now widely accepted that patients treated by allogeneic stem cell transplantation may be cured, but only a minority of CML patients are eligible for this procedure and the risks for morbidity and mortality directly attributable to the procedure remain appreciable. The majority of patients have hitherto been treated with hydroxyurea, interferon-α or interferon-α + cytarabine; with these approaches the median survival is about 6 years and none can be regarded as curative. The recent introduction of imatinib (imatinib mesylate, Glivec, formerly STI571) appears to constitute a major advance in the treatment of CML. The new molecule was found to inhibit the BCR-ABL tyrosine kinase activity, which represents the main pathogenetic mechanism in CML. The BCR-ABL gene is the chimeric gene produced by the t(9;22) translocation in CML and it encodes a protein with deregulated tyrosine kinase activity that is known to induce leukemia, deregulating signal transduction pathways and causing abnormal cell cycling, inhibition of apoptosis and increased proliferation of cells. Imatinib occupies the kinase pocket of the BCR-ABL protein and blocks access to ATP, thereby preventing phosphorylation of any substrate. The new agent has proved very effective in the treatment of CML patients, producing remarkable clinical benefits and very high grades of complete or major cytogenetic response. Although it is early to be sure, it is believed that this can be translated into better results in survival and disease progression. Imatinib now seems to be the initial treatment of choice for patients with CML, at least for those who are not candidates for transplantation. The incorporation of this drug in the treatment of young patients with a suitable bone marrow donor is a great challenge. As relapses using single agent imatinib have occurred, though infrequently, particularly in advanced phase patients with CML, the issue of whether its combination with other antileukemic agents may yield improved results is addressed.
Authors and Affiliations
V. GARYPIDOU
Keywords
Related Articles
- EP ID EP96606
- DOI -
- Views 88
- Downloads 0
Evaluation of information resources in biomedical sciences: PubMed, DIMDI <br /> <br />
The purpose of this investigation was to study the effectiveness of the mechanisms for knowledge management and intervention services in terms of production, distribution, management and dissemination of scientific infor...
Η έννοια της ποιότητας στην Ιατρική και τις υπηρεσίες υγείας
Στην παρούσα μελέτη γίνεται προσπάθεια ανασκόπησης της «ποιότητας» στην ιατρική πράξη και στην παροχή υπηρεσιών υγείας. Η ποιότητα στον τομέα της υγείας ταυτίζεται κυρίως με την παροχή των αναγκαίων και πλέον αποτελεσματ...
Ρευματικά νοσήματα της παιδικής ηλικίας.<br /> Επιδημιολογία, γενετική, περιβαλλοντικοί παράγοντες
Τα ρευματικά νοσήματα της παιδικής ηλικίας αντιπροσωπεύουν τα συνηθέστερα χρόνια νοσήματα της Παιδιατρικής και μια από τις σημαντικότερες αιτίες παιδικής αναπηρίας. Η συστηματική καταγραφή και παρακολούθηση των ασθενών,...
Skin diseases and inflammatory bowel disease. Part II. Nosological parallels, diagnostic problems and adverse effects of treatment: Fields for collaboration between gastroenterologists and dermatologists
In nosological terms, there is a striking pathophysiological resemblance between certain subgroups of skin and gastrointestinal diseases, probably as a result of the overall structural similarity of the two systems. Desp...
The incidence of electrical injuries in Messinia over the last 10 years
No abstract available