UMBELLIFERONE WITH VITAMIN C MODULATES LIPID PROFILE INDICES IN DIETHYLNITROSAMINE INDUCED HEPATOCELLULAR CARCINOMA
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 6
Abstract
Umbelliferone (UMB) and vitamin C are naturally available antioxidants with the capacity to inhibit the formation of tumors in several cancer models. In the present study, the authors have investigated if the combination of UMB and vitamin C had any role in lipid metabolism in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in rats. Rats were randomly distributed into 6 groups of 6 rats each. Rats in group 1 received standard pellet diet and served as controls. HCC was induced in Group 2 rats by providing 0.01 % DEN through drinking water for 15 weeks. Group 3 rats received UMB via intra gastric intubation at a daily dose of (30 mg/kg body weight) + vitamin C (200 mg/kg body weight) through drinking water for 16 weeks. Group 4 rats were pretreated with UMB + vitamin C, 1 week prior to the administration of DEN and it was also continued until the end of the experiment. Group 5 rats were post-treated with UMB + vitamin C for 5 weeks after the administration of DEN for 10 weeks and further continued until the end of experiment. Group 6 rats were treated with UMB + vitamin C along with DEN for the entire 15 weeks of experimental period. DEN-induced rats showed increased levels of total cholesterol and triglycerides and decreased levels of phospholipids and free fatty acids. These changes were reversed to near normal levels in groups treated with UMB + vitamin C. The histopathological and ultra-structural studies were performed to further confirm the occurrence of apoptotic morphological changes at the cellular level.
Authors and Affiliations
Revathi Ramalingam, Manju Vaiyapuri
Keywords
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- EP ID EP132244
- DOI 10.7897/2321-6328.02688
- Views 83
- Downloads 0
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