UMBILICAL CORD BLOOD BILIRUBIN AS A PREDICTOR FOR NEONATAL HYPERBILIRUBINEMIA
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 6
Abstract
Jaundice is a clinical condition that is often present in pediatric practice and constitutes one of the major issues within the neonatal period. It occurs in both the physiological and pathological processes in newborns. The present study was conducted to verify whether the bilirubin levels found in the cord blood at birth could be indicative of neonatal hyperbilirubinemia among healthy term neonates. 567 term neonates were included in the study and subjected to a cord blood analysis for serum bilirubin. Further at 72 hrs of life, blood for serum bilirubin was again collected and the two values compared. With Receiver operating characteristic analysis, a cutoff value of cord bilirubin level of ≥1.89mg/dL was determined which had the highest sensitivity (96.36%) to predict the newborns who would develop significant hyperbilirubinemia. In present study, the cord bilirubin level of >1.89 mg/dL had the highest sensitivity (96.36%), and this critical bilirubin level had a very high (99.45%) negative predictive value and fairly low (26.4%) positive predictive value this finding compatible with other studies. The cord bilirubin level of <1.89 mg/dL did not completely exclude the development of significant hyperbilirubinemia; only 0.546% of the newborns with cord bilirubin levels of <1.89mg/dL developed jaundice. A 99.45% negative predictive value in the present study suggests that measurement of cord serum bilirubin can help in identify those newborns who are unlikely to require further evaluation and intervention. Estimating cord bilirubin levels is a simple and non invasive screening test to predict those neonates who are at least risk of developing significant hyperbilirubinemia and unlikely to require further evaluation and intervention.
Authors and Affiliations
Dr. Jayalakshmi Pabbati*| Department of Pediatrics, Mediciti Institute of Medical Sciences, Ghanpur Village, Medchal Mandal, R.R District, 501401, India, Dr. Arvind G| Department of Pediatrics, Mediciti Institute of Medical Sciences, Ghanpur Village, Medchal Mandal, R.R District, 501401, India, Dr. Aravind Reddy V| Department of Pediatrics, Mediciti Institute of Medical Sciences, Ghanpur Village, Medchal Mandal, R.R District, 501401, India, Dr. Tajeswini N, Dr. Uma Ramachandran| Department of Pediatrics, Mediciti Institute of Medical Sciences, Ghanpur Village, Medchal Mandal, R.R District, 501401, India, Dr. (COL). CG Wilson| Department of Pediatrics, Mediciti Institute of Medical Sciences, Ghanpur Village, Medchal Mandal, R.R District, 501401, India
Keywords
Related Articles
- EP ID EP3470
- DOI -
- Views 369
- Downloads 15
To Evaluate the Clinical Efficacy of Combination of Low Dose Bisoprolol Fumarate and Low Dose Hydrochlorothiazide with Bisoprolol Alone in Stage I and II Hypertension
OBJECTIVE: Control of hypertension by the use of low dose combination therapy is associated with greater efficacy, less side effects and higher response rates as the result of complementary mechanisms of antihypertensiv...
Evaluation of Microbial Contamination of Eye Make up Product: Mascara
Eyes are one of the most important features when it comes to beauty. Various cosmetics are used to enhance their level of attractiveness like mascaras, eyeliners eye shadow among many more. Out of these above products ma...
POSTMENOPAUSAL OSTEOPOROSIS IN OBESE WOMEN
Obesity and osteoporosis are two common diseases with an increasing prevalence and a high impact on morbidity and mortality. Obese women have always been considered protected against osteoporosis. Fat and bone are linked...
AQUIRED IMMUNO DEFICIENCY SYNDROME AND ITS OPHTHALMIC MANIFESTATIONS. SHORT REVIEW ARTICLE.
Rising trend of HIV seropositivity in TB patients in India and involvement of multi organ system and multiple opportunistic infections in AIDS is quite worrying1-3. India is emerging globally as a country with the larges...
RECTAL MISOPROSTOL VS 15-METHYL PROSTAGLANDIN F2α FOR THE PREVENTION OF POST PARTUM HEMORRHAGE
1. To compare the efficacy and side effects of 400μg of rectal misoprostol with intramuscular 125μg PGF2α in prevention of postpartum haemorrhage.2. To estimate amount of blood loss during the third stage and duration of...