Unexpected insights in the aetiology and management of abdominal vein thrombosis
Journal Title: Journal of Hematology and Therapeutics - Year 2016, Vol 1, Issue 1
Abstract
Myeloproliferative neoplasms (MPN) – polycythaemia vera (PV) and essential thrombocythaemia (ET) are common causes of abdominal vein thrombosis (portal and hepatic veins). The JAK2 mutation is found in 50% of ET and 95% of cases of PV and should be a standard investigation for all cases of abdominal vein thrombosis. Two cases are presented of portal vein thrombosis due to underlying ET with normal or near normal platelet counts. There was a long delay in diagnosing the MPN in these two cases when relying on the current diagnostic criteria. These diagnostic classifications tend to miss cases of early or latent cases of ET, particularly those that are JAK2 negative. In JAK2 negative cases, diagnosis depends on marrow histology which is often unreliable. Moreover, the thrombotic risk is independent of the platelet count in ET and can occur even in ET with normal or mildly elevated platelets. Awareness of these possible scenarios can avoid debilitating thrombosis by the early institution of antiplatelet therapy.
Authors and Affiliations
Busuttil DP
Keywords
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- EP ID EP560095
- DOI 10.14312/2397-8694.2016-2
- Views 35
- Downloads 0
Unexpected insights in the aetiology and management of abdominal vein thrombosis
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