Update onarsenic Exposure Link inCancer
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 6
Abstract
Acute arsenic poisoning is uncommon, but inorganic arsenic exposure is worldwide. The highest affected areas are Bangladesh and West Bengal. Ground water most often gets contaminated due to agriculture and mining activities. Contributory factors include arsenic in the drinking water and through food. Inorganic arsenites(arsenic(III),in drinking water have a much higher acute toxicity than organic arsenates(arsenic(V).Arsenic interferes with cellular longevity by allosteric inhibition of essential metabolic enzyme pyruvate dehydrogenase (PDH) complex, which catalyzes the oxidation of pyruvate to acetyl-CoA by NAD.The common symptoms of arsenic poisoning include headache confusion, severe diarrhea, anddrowsiness. Acute symptoms may include diarrhea, vomiting, vomiting blood, blood in urine, and convulsions, Body organs affected are the lungs,skin, kidneys and liver, and eventuallycoma and death. Arsenic increases the risk of cancer, heart disease, stroke, chronic lower respiratory diseases and diabetes. Arsenic may be measured in blood, urine hair, and finger nails. DMSA monoesters are promising antidotes for arsenic poisoning.
Authors and Affiliations
Murtaza Mustafa, RK. Muniandy, EM. Ellzam, HM. Iftikar, K. Fairrul, MK Nang, AM. Sharifa
Keywords
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