Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 3
Abstract
Background: Hyperuricemia and diseases related to hyperuricemia have been recognized among Filipinos in different countries. Diseases related to hyperuricemia such as gout and increased risks of cardiovascular diseases have given an avenue for methods on lowering uric acid levels. Aims and Objectives: Manilkara zapota, commonly known as Chico, has been reported to have the potential to reduce the uric acid level and thus was tested using aqueous leaf extracts of the plant. Materials and Methods: The plant was administered at a low dose of 1g/kg body weight (BW) and a high dose of 3g/kg BW on 10–16-week-old male ICR mice for 28 days. Three control groups were used for comparison of results: The sham group was administered with sterile distilled water and was not treated with KBrO3 , a positive control group was administered with ascorbic acid instead of the leaf extract and was treated with KBrO3 , and a negative control group was administered with sterile water and was also treated with KBrO3 . Hyperuricemia was induced using KBrO3 on the last day to detect for uric acid lowering activity. Results: Analysis shows that the negative control group had the highest mean of uric acid levels after hyperuricemia induction resulting to a significant difference from among the other groups. The mean uric acid levels of the groups treated with the leaf extract and ascorbic acid after hyperuricemia induction did not have any significant difference from each other. Conclusion: There is a urate-lowering activity from Manilkara zapota aqueous leaf extracts that are possibly due to the presence of flavonoids.
Authors and Affiliations
Maria Gabriela G Cervero, James Ellard D Sy, Michael B Ples, Rodel Jonathan S Vitor II
Keywords
Related Articles
- EP ID EP487187
- DOI 10.5455/njppp.2017.7.1039309112017
- Views 121
- Downloads 0
Evaluation of immune status of young female during different phases of menstrual cycle
Back ground: Menstruation is characterized by monthly rhythmical changes in the rates of secretion of the female sex hormones and corresponding physical changes in the ovaries and other sexual organs. There are th...
The muscular effect of Cobra energy drink on toad (Bufo marinus = Rhinella marina) gastrocnemius fatigue time and contraction force
Background: Cobra energy drink is one of the most popular beverages in the Philippines used by many for its energy-boosting effects. It is known to contain ingredients such as caffeine, B-vitamins, taurine, and ginseng,...
Association of ABO blood group with different constitutional types
Background: Tridosha and Prakriti are the fundamental principles of Ayurveda which forms the basis of individualized approach of Ayurveda for health and diseases. All individuals have the same blood group system, but dif...
Blood pressure variations in textile mill middle-aged male workers exposed to noise
Background: Continuous exposure to occupational noise may create physiological derangements of parameters pertaining to stress and anxiety of an individual’s life. Controversial outcomes over the years from different stu...
Evaluation of lung function tests in rheumatoid arthritis patients
Background: Pulmonary manifestation is one of the most common extra-articular features in rheumatoid arthritis (RA) leading to significant morbidity. Lung function testing helps in identifying the type of respiratory def...