Uric acid as a cardiovascular risk factor
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2007, Vol 24, Issue 6
Abstract
The relationship between high plasma levels of uric acid and cardiovascular disease was described for first time at the end of the 19th century. Since then several epidemiological and clinical observations on the topic have been reported, but the data on the relationship between serum uric acid and cardiovascular disease in the general population are contradictory. Recent studies suggest that high serum uric acid levels may be an independent risk factor for cardiovascular disease in individuals already at high risk, such as patients with diabetes mellitus, hypertension and heart failure. Intervention with medications which reduce serum uric acid levels is associated with reduction in cardiovascular morbidity and mortality. Several potential mechanisms have been proposed to explain the association between high serum uric acid levels and cardiovascular disease, including increased platelet adhesiveness, oxidative stress, endothelial dysfunction and smooth muscle cell proliferation in patients with hyperuricemia. Large-scale prospective trials, especially in high-risk individuals, are needed to clarify the potential relationship between hyperuricemia and cardiovascular disease.
Authors and Affiliations
A. PAPAZAFIROPOULOU, N. TENTOLOURIS
Keywords
Related Articles
- EP ID EP123703
- DOI -
- Views 81
- Downloads 0
A young patient with mild clinical picture and pathologic chest x-ray
No abstract available
Η αύξηση των ασθενών σε θεραπεία υποκατάστασης της νεφρικής λειτουργίας. <br /> Παγκόσμιο φαινόμενο με σοβαρές επιπτώσεις
Ο αριθμός των ασθενών σε θεραπεία υποκατάστασης νεφρικής λειτουργίας (ΘΥΝΛ) με αιμοκάθαρση (ΑΜΚ), περιτοναϊκή κάθαρση (ΠΚ) ή μεταμόσχευση νεφρού (ΜΝ) αυξήθηκε με αλματώδεις ρυθμούς τις τελευταίες δεκαετίες. Παρά το γεγον...
Pityriasis lichenoides chronica
No abstract available
Adhesion molecules; novel tools in the cancer jigsaw <br />
In the present study the topic of adhesion molecules regarding their involvement in the whole carcinogenetic process is discussed in detail. Until now, more than a hundred adhesion molecules have been fully identified, a...
New documents regarding the chair of the History of Medicine <br /> at the National University of Athens <br /> <br />
History of Medicine was the first subject chosen in the syllabus of the Medical School of Athens National University, which was founded in 1837. The subject was taught by professor Anastasios Georgiadis-Lefkias who was a...