Urinary Cystatin C as an Early Biomarker of Acute Kidney Injury in Critically ill Patient
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
Introduction: Acute kidney injury is associated with high mortality in critically ill patients. We usually measure serum creatinine to detect AKI, but it is a poor predictor of accuracy particularly in the early stages of AKI(1) . We studied the utility of urinary cystatin C and its significance in AKI. Materials and Methods: This prospective observational study was done in 83 critically ill patients admitted in ICU. Serum creatinine was done on day 1 and day 3 which was compared with Urinary Cystatin C done on day 1. Results: Out of the 83 patients, 36 (43.3%;) developed AKI. Serum creatinine on day 1 and day 3 were compared with urinary cystatin C done on day 1. We observed that in the AKI group there was significant elevation of urinary cystatin C (15% (p=0.001)). On contrary in the non AKI group there was a marginal level of increase in urinary cystatin C. As the urinary cystatin C is the early excretory product it can be used as an early biomarker of AKI. Conclusions: We found that the urinary cystatin C levels were significantly elevated in AKI groups when compared with the creatinine levels. Hence we suggest that urinary cystatin C is a significant early biomarker for AKI. Moreover, further studies are warranted with large number of sample size with multicentric population to confirm these results
Authors and Affiliations
Dr Karthik . B
Keywords
Related Articles
- EP ID EP515573
- DOI -
- Views 69
- Downloads 0
Clinical Spectrum and Etiology of Seizures in Children in Age Group of Two Months to Twelve Years: A Cross Sectional Observational Study
Background: Not only the incidence, clinical profile and etiology of seizures vary between populations. This knowledge is very useful for health care planning by health care providers. Method : A total of 1...
An Observational Study of Clinical Features of Scrub Typhus
Objectives: Scrub typhus is a mite borne disease caused by Rickettsia tsutsugamushi. Because of the unpredictability and difficulty in diagnosis, it can sometimes be serious in pediatric age groups and fatality rate is a...
A Study of Clinical and Epidemiological Profile of Dengue Fever in Tertiary Care Centre in Central India
Objective: Dengue fever is most important arboviral disease in India and other tropical and subtropical countries with increasing prevalence in recent years with significant morbidity and mortality. This study was aimed...
A Comparative Study between Conventional Dose of Hyperbaric Bupivacaine Alone & a Combination of lower Fose of Hyperbaric Bupivacaine with Fentanyl for Subarachnoid Block in Turp Surgery among Elederly
It is universally agreed that the anaesthesia of choice for TURP is a sub arachnoid block and a sensory level of T-10 is recommended to provide excellent anaesthesia and acceptable condition for the patient 1 . Subarachn...
Profile of type-2 diabetes mellitus with and without complications
Objective: To describe the profile of type-2 diabetes patients. Methods: This was a cross-sectional study conducted in tertiary care hospital. A total of 50 cases of diabetes with and without complication with 35-75 year...