URINARY TRACT INFECTION, ITS CAUSATIVE MICROORGANISMS AND ANTIMICROBIAL SUSCEPTIBILITY OF ENTEROBACTERIACEAE ISOLATES IN AND AROUND PARBHANI
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 18
Abstract
BACKGROUND Urinary tract infection (UTI) remains a major public health problem and occurs in all populations and age groups. However, urinary tract infection is fourteen times more common in females than males, especially sexually active women. Among both outpatients and inpatients, Escherichia coli is the primary pathogen followed by Staphylococcus saprophyticus, Klebsiella species, Proteus species, Enterococcus species and Enterobacter species. Recurrent UTIs warrant the use of multiple courses of antibiotic therapy. Eventually, the risk of antibiotic-resistant organisms is increased. To provide appropriate antibiotic treatment, physicians need to know local patterns of antimicrobial susceptibility for proper drug selection. Therefore, this study was done to determine the prevalent microorganisms causing UTI and their antimicrobial susceptibility patterns in and around Parbhani. MATERIALS AND METHODS The present retrospective descriptive study was carried out during July 2016 to December 2017. A total of 650 urine samples were collected for study. Patient’s age, parity, history of urinary complaints, past history of diabetes and hypertension was documented. Mid-stream urine samples were collected in a sterile wide mouthed container. Microscopic and macroscopic examination of urine was done. Plating of urine sample was done using standard loop technique. After incubation, plates were examined for any growth and colony count measured. Bacterial identification and antimicrobial susceptibility was done using VITEK 2 compact 30. RESULTS Among 650 samples tested, 220 (20.73%) were positive for pathogenic organisms. Escherichia coli of 49.09% was the most common. This was followed by Klebsiella species 45 (20.45%) and Pseudomonas species 19 (8.63%). In the present study, burning micturition was the commonest (40.05%) complaint of UTI. E. coli, the most frequently isolated bacterium showed high resistance rates (> 80%) to Ampicillin and Nalidixic acid. Majority (96.3%) of E. coli isolates were susceptible to amikacin with resistance rate of 3.8%. Klebsiella species showed most resistance to Nalidixic acid (86.66%) followed by Ampicillin (84.44%), while Fosfomycin and amikacin (75.56 %) were most susceptible antimicrobials. CONCLUSION A continuous review of antibiograms is necessary to track changes in aetiological agents and antimicrobial patterns to help in empirical treatment.
Authors and Affiliations
Prafulla Shrikant Patil, Kiran Bhagwanrao Sagar, Renu Shekhar Pande
Keywords
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- EP ID EP418057
- DOI 10.14260/jemds/2018/502
- Views 98
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