Use of Immunomarkers D2-40 and CD31 in Detection of Lymphovascular Invasion in Breast Carcinoma
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 7
Abstract
Breast cancer is a major health problem in the world. It is a disease with significant morbidity and mortality. Metastasis and recurrence are the main causes of mortality in breast carcinoma. Lymphovascular invasion is associated with increased axillary node metastasis and recurrence. Identifying lymphovascular invasion (LVI) is difficult in haematoxylin and eosin stained slides especially if lumen is completely filled by tumour cells or when retraction artefacts is present. D2-40 is a sensitive and specific marker to detect tumour cells in lymphatic vessels. It selectively and specifically stains lymphatic endothelial cells. CD31 is a 130 kDa transmembrane glycoprotein in the immunoglobulin super family. CD31 stains blood and lymph vessels. Staining with these immunomarkers makes it easy to identify the invasion. If it is identified more aggressive therapy can be given to the patient which will reduce the recurrence rate in carcinoma breast patients.
Authors and Affiliations
Dileep A P
Keywords
Related Articles
- EP ID EP487158
- DOI -
- Views 77
- Downloads 0
A Cross-sectional Study of Profile Serum Lipid levels in off-springs of Diabetic patients in a Tertiary Care Hospital in Central India
Aims & Objective: To compare various serum lipid parameteres in young healthy off-spring of diabetics (single or both parents) with offspring of non-diabetic parents. Material and Methods: A cross sectional study with 12...
Comparative Trial of Phenobarbitone vs Phenytoin in Moderate and Severe Perinatal Asphyxia in Term Neonates
A prospective, hospital-based open-label randomised trial was conducted with primary aim to compare the clinical seizure control after administration of either drug, Phenobarbitone or Phenytoin in term neonates with mode...
External Validation of PCOS Questionnaire in Assessing Quality of Life in Females with PCOS Based on Lifestyle Changes with Therapeutic Measures like OC Pills and Metformin
Abstract Background: The aim was to study the effect of metformin in a lifestyle modification program combined with oral contraceptive pills on quality of life parameters measured by PCOS questionnaire in women and valid...
Sexual Dysfunction among Men with Alcohol Dependence Syndrome in a Tertiary Care Hospital, Puducherry
Background: Alcohol is a depressant and using it regularly can dampen mood and cause sexual dysfunction on the longer run .Many alcoholics often suffer from severe sexual problems as the result of their drinking. The obj...
The Incidence of Diarrhea in Babies Affected through the Cleanliness of Eating Utensils and Hands
Background: In Bandar Lampung, the highest case of diarrhea in the <1 year age group occurred in Simpur Health Center, amounting to 9.73% exceeding the incidence in Bandar Lampung City, the capital, at 2.68%. The Objecti...