Use of Partial Area under the Curve Metrics to Assess Bioequivalence of Methylphenidate Multiphasic Modified Release Formulations
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 4
Abstract
Authors and Affiliations
Ethan M. Stier, Barbara M. Davit, Parthapratim Chandaroy, Mei-Ling Chen, Jeanne Fourie-Zirkelbach, Andre Jackson, Stephanie Kim, Robert Lionberger, Mehul Mehta, Ramana S. Uppoor, Yaning Wang, Lawrence Yu, Dale P. Conner
A Novel Ultrasensitive Hybridization-Based ELISA Method for 2-Methoxyphosphorothiolate MicroRNAs and Its In vitro and In vivo Application
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that bind to target mRNAs and regulate their expression. Recent evidence has indicated the involvement of miRNAs in human malignancies. It has been suggested that...
Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters
The online version of this article (doi:10.1208/s12248-010-9225-x) contains supplementary material, which is available to authorized users.
Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels
The development of zero-order release systems capable of delivering drug(s) over extended periods of time is deemed necessary for a variety of biomedical applications. We hereby describe a simple, yet versatile, delivery...
Varying polymer architecture to deliver drugs
Variable architecture polymers are of considerable interest for the delivery of therapeutic biopolymers, such as DNA and proteins, to their site of action. Polymers that can respond with a change in conformation to biolo...
Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans
Ginger extracts have been studied in various clinical trials for different indications. However, the pharmacokinetics of the ginger active constituents in human biological matrices is not well investigated. This study ai...