UTILITY OF PLACENTAL LEUCINE AMINOPEPTIDASE/OXYTOCINASE IN THE PREDICTION OF PRETERM DELIVERY IN PREGNANT WOMEN WITH THREATENED PRETERM LABOR
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 4
Abstract
Objective: The study objective was to assess the utility of placental leucine aminopeptidase (P-LAP) marker for the prediction of delivery in patients presented with threatened preterm labor (TPL). Setting: This study was conducted at the Obstetrics and Gynaecology Department of Al-Yarmouk Teaching Hospital in the period from March 2017 to June 2018. Type of Study: This is a prospective case control study. Methods: This study included 90 pregnant women with gestational age from (28-36+6) weeks; 45 of them who presented with preterm uterine contractions were considered as the study group which was further subdivided into three subgroups according to gestational age 28–31+6 weeks, 32– 33+6 weeks, and 34–36+6 weeks. The other 45 pregnant women who presented to the hospital for regular antenatal care visit at comparable gestational age to the study group were considered as the control group. Hence, this study aimed to assess the serum level of P-LAP in both groups and compare it between those delivered preterm from term to assess its applicability as a predictor of preterm labor. Results: Serum level of P-LAP in pregnant women presented with TPL was found to be significantly lower in those delivered preterm (p<0.001), compared to those continued to term and control group especially in gestational ages ≥32 weeks, while the study found P-LAP level to be statistically insignificant in gestational age <32 weeks (p=0.052). The cutoff point for P-LAP serum level was = 21 (IU/ml) that below it, the pregnant women with TPL most probably deliver before 37 weeks of gestation with Sensitivity (85.7%) Specificity (90.3%), Positive predictive value (80.0%) Negative predictive (93.3%). Conclusion: The serum level of P-LAP was lower in women delivered preterm than those delivered at term, so it can be used as one of the markers for the prediction of preterm delivery, especially at gestational age >32 weeks.
Authors and Affiliations
MIAMI ABD–AL HASSAN , ISRAA TALIB ABD AL KADIR , NOOR HUMAM MOHAMMED
Keywords
Related Articles
- EP ID EP604695
- DOI -
- Views 113
- Downloads 0
ASSESSMENT OF ANTIOXIDATIVE AND AMELIORATIVE POTENTIAL OF AQUEOUS EXTRACT OF LEAVES OF THUJA ORIENTALIS (PLATYCLADUS ORIENTALIS [L.])
Objective: The main objective of the present study is to assess the antioxidative and attenuating potential of aqueous extract of leaves of Thuja orientalis (AET) against the genotoxicity induced by chlorpyrifos (CPF) (O...
ANTIOXIDANT ACTIVITIES AND TOTAL PHENOLIC AND FLAVONOID CONTENT VARIATIONS OF LEAF EXTRACTS OF LAURUS NOBILIS L. FROM MOROCCO
Objective: The present study was undertaken to determine antioxidant activity and total phenolic and flavonoid content of ethanol, methanol, ethyl acetate, and aqueous extracts of the leaves of Laurus nobilis L.Methods:...
EVALUATION OF ANTICONVULSANT ACTIVITY OF PREMNA HERBACEA (ROXB.) EXTRACTS IN PENTYLENETETRAZOL AND MAXIMAL ELECTROSHOCK-INDUCED CONVULSIONS IN MICE
Objective: In the present study, three different extracts of Pemna herbacea (Roxb.) were evaluated for its anticonvulsant activity against pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced convulsions in mic...
MIMOSINE - A NOVEL SUBSTANCE AND EVALUATE THE LIPID PEROXIDATION
Objective: The mimosine is a novel substance extracted and purified from Mimosa pudica. The present study is to evaluate lipid peroxidation (LPO). Methods: The sox halation is used to differentiate extracts. Mimosine is...
SURGICAL SITE INFECTION RELATED RISK FACTORS AND USAGE OF ANTIBIOTICS IN TWO DIFFERENT TERTIARY CARE HOSPITALS OF DHAKA CITY, BANGLADESH
Objective: Surgical site infection (SSI) is the most common complications following surgical procedures. The aim of the study was to assess the risk factors for SSI and the antibiotic treatment pattern following post-ope...