Utilizing Adipose Tissue-Derived Stem Cell Strategies for Obtaining Regeneration of Respiratory Tract Fistulas-A Systematic Review
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2020, Vol 1, Issue 2
Abstract
Fistula of the respiratory tract represent an aberrant communication or passage among the respiratory system as well as the digestive tract or the nearby organs. They might originate congenitally or more commonly, iatrogenic with a heterogeneous presenting features. These fistulas of the respiratory tract might cause decreased health-associated Quality of Life (QOL) as well as short lifespan. Treatment is basically dependent on an endoscopic surgical procedure but mostly patients need continued hospitalization as well as might develop complications. Thus with the advent of stem cells, the more conservative strategies utilizing regenerative medicine strategies basically dependent on lipotransfer, have been evaluated. After having reviewed the role of Adipose Tissue-Obtained Stem/Stromal Cells (ASC’S) in various kinds of regenerative medicine, here we tried to conduct a systematic review on ASC. Adipose Tissue (AT) might be administered in the form of unprocessed tissue or subsequent to enzymatic treatment to be able to obtain the cellular Stromal Vascular Fraction (SVF).Thus here we conducted a systematic review on the same. With role of stem cells be it Mesenchymal Stem/Stromal Cells (MSCs) or Adipose tissue-derived stem/ stromal cells (ASC’S) in the repair of respiratory tract fistulas. Utilizing the Pubmed search Engine, along with Google Scholar ,Web of Science Scopus, Clinicaltrials.gov for clinical trials utilizing MeSH terms like Bronchopleural Fistula (BPF); to Tracheooesophageal Fistula (TEF); Mesenchymal Stem Cells (MSCs); Mesenchymal stromal cells; Adipose tissue-derived Stem/ Stromal Cells (ASC’S); respiratory tract fistulas; post cancer head and neck fistulas; lipoaspirate from 1960-2020 till date . We found a total of 175 articles out of which we selected 110 articles for this review. No meta-analysis was done. With minimal clinical experience maximum of which comes from case reports as well as case studies, a total concluding proof is still not there. But definitely it is a gradually evolving field with more experience gained, grafting of adipose tissue obtained stem/stromal cells might turn out to me the least invasive as well as more conservative therapy alternative towards the more mutilating damaging extensive surgeries. The safety as well as tolerance observed in earlier studies might aid in strategizing as well as designing larger designs in future which might utilize novel methods with regards to tissue processing along with utilization of scaffolds as well as 3D printing in the longer plans for enhancing the clinical results.
Authors and Affiliations
Kulvinder Kochar Kaur*, Gautam Allahbadia, Mandeep Singh
Keywords
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- EP ID EP698850
- DOI http://dx.doi.org/10.46889/JRMBR.2020.1205
- Views 69
- Downloads 0
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