UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF SOLIFENACIN SUCCINATE IN TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Solifenacin succinate (5mg) in tablets and validate as per ICH guidelines.Methods: The optimized method uses a solvent 100% triethylammonium phosphate buffer (pH 2.5) for the estimation of assay of Solifenacin succinate in tablets at a detection wavelength of 215 nm.Results: The developed method resulted in Solifenacin succinate exhibiting linearity in the range 5-15μg/ml. The precision is exemplified by relative standard deviation of 1.27%. Percentage Mean recovery was found to be in the range of 98â€102, during accuracy studies. The limit of detection (LOD) and limit of quantitiation (LOQ) were found to be 1.106mg/ml and 3.35mg/ml respectively.Conclusion: A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Solifenacin succinate in tablets as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.Â
Authors and Affiliations
Rakesh Bhooshanavoyina, Bhargavi Pathuri, Rakesh Reddy Soma, Ashok Kumar Akuthota
Keywords
Related Articles
- EP ID EP579426
- DOI -
- Views 88
- Downloads 0
EFFECT OF GARLIC (ALLIUM SATIVUM L) ON BIOCHEMICAL PARAMETERS AND HISTOPATHOLOGY OF PANCREAS OF ALLOXAN-INDUCED DIABETIC RATS
Objective: Garlic (Allium sativum. L) plays an important dietary role, as well as medicinal, for centuries. Even today the use of garlic is widespread and growing. The present study investigated the effect of garlic extr...
AN INNOVATIVE STRATEGY BASED ON UNCERTAINTY PROFILE FOR THE VALIDATION OF MICROBIOLOGICAL METHODS FOR COUNTING ENTEROBACTERIACEAE IN FOODS
Objective: A new and powerful statistical approach known as the uncertainty profile concept has been suggested for both testing the validity and making easy and straightforward interpretation of results obtained during t...
IN VITRO EVALUATION OF NAPROXEN SODIUM AND ACETAMINOPHEN FROM FIXED-DOSE COMBINATION GENERIC DRUGS USING THE FLOW-THROUGH CELL METHOD
Objective: The aim of this study was the in vitro evaluation of naproxen sodium and acetaminophen from fixed-dose combination generic drugs based on the hydrodynamic environment generated by the flow-through cell method...
THE 2α-3β-6β-23-TETRAHYDRO-OLEAN-12-EN-28-OIC ACID FROM THE LEAVES OF CHRYSOBALANUS ICACO L. ATTENUATES THE INFLAMMATORY HYPERNOCICEPTION IN MICE
Objective: The species Chrysobalanus icaco L., popularly known as abajurú, abajeru, has frequently been associated with antiangiogenic, anti-inflammatory and antirheumatic effects. The 2α-3β-6β-23-tetrahydro-olean-12...
INFLUENCE OF LOCALLY APPLIED HEAT ON THE PERFORMANCE OF TRANSDERMAL DICLOFENAC SODIUM PLASTERS
Objective: Applied heat to dermatologic preparations influences the medicine’s performance, such as drug release rate and drug absorption. However, there is little information concerning the performance of non-steroid...