Vaginal administration of isosorbide mononitrate for cervical ripening prior to induction of labor for postdated pregnancy: a randomized controlled trial
Journal Title: Journal of BP Koirala Institute of Health Sciences - Year 2018, Vol 1, Issue 1
Abstract
Introduction: Induction of labor is commonly practiced intervention in modern Obstetrics. The aim of induction of labor is to initiate labor when maternal and fetal conditions necessitate delivery before the onset of spontaneous contraction with purpose to achieve safe vaginal delivery. Induction of labor is one of the most commonly practiced interventions in the Department of Obstetrics and Gynecology every day. The success of this obstetric practice is highly dependent upon the condition of the cervix which is assessed with Bishop‟s Score and it is well known that unfavorable cervix is associated with failure of induction and cesarean section. In the recent years, there has been a considerable interest in the use of nitrous oxide donors for cervical ripening and labor induction. Objective: To evaluate whether isosorbide mononitrate administered vaginally prior to induction in postdated pregnancy is effective for pre-induction cervical ripening and thus, improves the process of induction of labor. Methods: One hundred and twenty women scheduled for labor induction were recruited and assigned randomly to isosorbide mononitrate or placebo followed by misoprostol 25μg. The efficacy of the medication was evaluated by predetermined outcome variables for cervical ripening and induction of labor and delivery. Results: The groups were comparable with respect to age, gestational age and Bishop‟s score. Women receiving isosorbide with misoprostol didn‟t show any improvement in the Bishop‟s score compared to misoprostol and placebo. There was no significant difference between the two groups regarding time of delivery and onset of active stage of labor from induction. Cesarean delivery rates were similar between the two groups; however, the indications of the cesarean section were different between the two groups which were significant statistically. Neonatal outcome were similar between the two groups. Conclusion: The addition of vaginal isosorbide mononitrate to oral misoprostol for cervical ripening and labor induction did not reduce time to vaginal delivery and didn‟t help in improving pre-induction cervical score.
Authors and Affiliations
Rubina Rai
Keywords
Related Articles
- EP ID EP422326
- DOI -
- Views 130
- Downloads 0
Questionnaire survey on methods of determining the relationship of the mandibular canal and third molars
Background: Clinicians should assess and monitor mandibular canal (MC) to achieve an uneventful and successful final result. Two dimensional techniques like panoramic radiography, intra oral periapical radiographs are co...
A change in name Health Renaissance is now Journal of BPKIHS
Editorial
Ziehl Neelsen vs. Auramine staining technique for detection of acid fast bacilli
Background: The culture and molecular test are the best methods for isolation and identification of Mycobacterium tuberculosis in developed countries. But, in developing countries like Nepal with a significant number of...
Histopathological spectrum of upper gastrointestinal endoscopic biopsies
Background: Upper gastrointestinal tract disorders are one of the most commonly encountered problems in the clinical practice. A variety of disorders can affect the upper gastrointestinal tract. Endoscopy, in combination...
Endoscopic medial maxillectomy for sinonasal inverted papilloma
Background: Traditionally, medial maxillectomy was performed through lateral rhinotomy or mid facial degloving approach for inverted papilloma. Endoscopic medial maxillectomy, since reported first in 1992, has advanced t...