VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DEXRABEPRAZOLE AND DOMPERIDONE IN BULK AND TABLET DOSAGE FORM
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 2
Abstract
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Domperidone and Dexrabeprazole, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 150mm, 5μm) column using a mixture of Methanol: Phosphate Buffer pH 3.5 (65:35) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 270 nm. The retention time of the Domperidone and Dexrabeprazole was 2.456, 4.312 ±0.02min respectively. The method produce linear responses in the concentration range of 5- 25mg/ml of Domperidone and 2.5-12.5mg/ml of Dexrabeprazole. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations
Authors and Affiliations
Gangavath Kalpana Devi , G. Rajitha
Keywords
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