Valuable Modern Strategy (ATR-IR) Spectroscopy Technique to Distinguish Between Normal and Lung Cancer Tissue
Journal Title: Middle East Journal of Cancer - Year 2019, Vol 10, Issue 1
Abstract
Background: Diagnosis of lung cancer is often delayed because most of the patients are asymptomatic during the primary cancer stages. Infrared spectroscopy is an improved technique compared with the others for identifying abnormal tissue types because of its spatial and spectral capabilities. Therefore, this study is taking an advanced advantage of the physical and optical properties of the attenuated total reflection Fourier-transform infrared system. Methods: The attenuated total reflection Fourier-transform infrared has been applied for cancer detection at infrared wavelengths that range from 4000-400 cm-1. This technique may be a beneficial diagnostic method because it uses the principles of physics, as optics and photonics with a specific wavelength region, which can make an immense difference. Results: The attenuated total reflection Fourier-transform infrared system spectra of normal lung tissue showed main peaks at 3321 and 1637 cm-1, which has been assigned to the OH and C=O function group of amide I and has intensities of approximately 61% (OH) and 76% (C=O). That intensity has been shown to decrease in the cancer tissue. A new peak at 1545 cm-1 appeared in the cancerous tissue, which could be an amide II. Conclusions: The identification of a biochemical component from either normal or cancerous lung tissue would help to evaluate malignant tissue. Thus, the obtained results indicated degradation of the biochemistry component (protein) of the tissue due to carcinogenic disease.
Authors and Affiliations
Ammar Alhasan, Ali Tammar Hussein
Keywords
Related Articles
- EP ID EP443508
- DOI -
- Views 99
- Downloads 0
Association of Epstein-Barr virus with Esophageal Squamous Cell Carcinoma
Introduction: Esophageal squamous cell carcinoma is among the leading causes of cancer related deaths within gastrointestinal tumors. There is a growing body of evidence that shows an association between Epstein Barr vir...
Evaluation of Promoter Hypermethylation of Tumor-Suppressor Genes p14 and p16 in Iranian Endometrial Carcinoma Patients
Background: Endometrial cancer is a common gynecological malignancy with good prognosis in the early stages of the disease. The CpG island in the promoter region of tumor-suppressor genes are frequently methylated in var...
Clinical Outcome of Tamoxifen and Sulindac for Desmoid Tumors in Adults: A Phase II Single Institution Experience
Background: Desmoid tumors are rare soft tissue neoplasms that have a variable and often unpredictable clinical course. We have conducted a phase II study to evaluate the efficacy and safety of tamoxifen and sulindac in...
The Role of miR-143, miR-145, and miR-590 in Expression Levels of CD44 and Vascular Endothelial Cadherin in Oral Squamous Cell Carcinoma
Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer with a continuing rise of incidence in developing countries. Despite the improvement in the clinical outcome of OSCC, the overall 5-...
Trends in Cervical Cancer Incidence in Iran from 2003 to 2009
Background: Cancer is the second leading cause of death worldwide and the third in Iran. Among cancers, cervical cancer is the third leading cause of death in women. Thus, recognizing the epidemiology and trends of cervi...