Value of TOX Immunoexpression in the Diagnosis of Early Mycosis Fungoides
Journal Title: Middle East Journal of Cancer - Year 2019, Vol 10, Issue 2
Abstract
Background: The lack of a specific marker to differentiate malignant from reactive T-cells makes a definite diagnosis difficult in patients suspected of having mycosis fungoides. This study has evaluated value of thymocyte selection-associated high mobility group box factor expression in the differentiation of early mycosis fungoides from a benign inflammatory dermatosis. Methods:We selected 22 mycosis fungoides cases, 18 cases suspicious for mycosis fungoides, and 12 cases of eczematous dermatitis from patients who attended Dermatology Clinic, Shiraz University of Medical Sciences (2008-2015). The obtained skin biopsies were immunostained for thymocyte selection-associated high mobility group box factor antigen in addition to pan T cell markers. The slides were evaluated for the percentage of tumor cells and intensity of immunoreactivity. Results: From 22 cases of mycosis fungoides, 40.9% showed massive infiltration of thymocyte selection-associated high mobility group box factor-positive lymphocytes (>30%) with high (3+) intensity in the epidermis; there was no case negative for thymocyte selection-associated high mobility group box factor expression. Only one eczematous dermatitis case had expression of thymocyte selection-associated high mobility group box factor-positive lymphocytes (>30%) with high intensity and 4 cases were negative for thymocyte selection-associated high mobility group box factor expression. The frequency of thymocyte selection-associated high mobility group box factor expressing lymphocytes was higher in biopsies from mycosis fungoides compared to eczematous dermatitis (P<0.05). CD7- cases expressed more thymocyte selection-associated high mobility group box factor-positive lymphocytes in the dermis and epidermis, which were significantly correlated (P=0.013). Conclusion: Thymocyte selection-associated high mobility group box factor, as a positive marker, in combination with pan T cell markers (especially CD7-) can be useful to detect mycosis fungoides malignant lymphoid cells.
Authors and Affiliations
Fatemeh Sari Aslani, Akbar Safaei, Hale Ghezelbash, Mozhdeh Sepaskhah
Keywords
Related Articles
- EP ID EP638865
- DOI 10.30476/mejc.2019.78531.
- Views 74
- Downloads 0
Prognostic Significance of MGMT Promoter Methylation in Patients with Glioblastoma Undergoing Surgical Intervention: A Retrospective Study in Northeastern Iran
Background: The standard of care for glioblastoma is concurrent chemoradiotherapy and adjuvant chemotherapy with Temozolomide. In this trial, we have investigated the impact of MGMT promoter methylation on prognosis and...
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background: Geographic differences in the incidence of cancers may suggest unique genetic or environmental exposures that impact the risk of acquiring cancer. This research aims to determine the incidence rate and geogra...
Epidemiology of Lung Cancer in Iran: Sex Difference and Geographical Distribution
Background: Lung cancer is one of the most common cancers and most frequent cause of cancer-related death worldwide. In Iran, this cancer ranks second in cancerrelated deaths for men and third for women. The aim of this...
Thyroid-like Follicular Carcinoma of the Right Kidney: A Case Report
Renal cell carcinoma is responsible for approximately 80% of malignant tumors of the kidney. Clear cell, papillary, and chromophobe forms comprise the most frequent histological subtypes of renal cell carcinoma. Thyroid-...
Myxofibrosarcoma of the Breast in a Young Pregnant Woman: A Case Report and Review of the Literature
Sarcomas of the breast are rare and comprise less than 1% of mammary cancers. Myxofibrosarcoma as an unusual variant of malignant fibrous histiocytoma in the breast and during pregnancy has not previous been reported in...