Vascular Events during Chemotherapy in Treatment of Germ Cell Testicular Cancer
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2015, Vol 5, Issue 3
Abstract
Introduction: We report a case of acute myocardial infarction and acute cerebral infarction during treatment with bleomycin, etoposide, and cisplatin (BEP) regimen for germ cell testicular cancer. Case Presentation: A 28 year old smoker man diagnosed with germ cell testicular cancer without any history of ischemic heart disease complained of sudden chest pain on day 6 of his second cycle of chemotherapy. His electrocardiogram showed Q waves (Lead V1–V3) and T wave inversion (Lead V1–V3). He underwent primary percutanoeous coronary intervention (PCI) to the proximal left artery descending (LAD) lesion (95%) with thrombus aspirated with export catheter and predialated with percutaneous transluminal coronary angioplasty (PTCA) and bar metal stent (BMS) deployed in the LAD. One week later; the patient developed left sided weakness and ptosis of left eyelid. Magnetic resonance angiography and venography to the head and neck showed total occlusion of left vertebral artery. Discussion: Acute MI and cerebral infarction are uncommon in young man without cardiovascular risk factors such as hypertension, diabetes, or dyslipidemia. Thromboembolic events (TEEs) are more likely in our case presented without significant risk factors; which was confirmed in our case by coronary angiography. Consclusion: Thromboembolic events are adverse events associated with chemotherapy treatment that may need further attention in regard to the initial prevention including pharmacological prophylaxis and possibility of an alternative regimen particularly in patients with testicular germ cell tumor.
Authors and Affiliations
Ahmed Mahfouz, Nahla Mousa, Ashraf Fawzy, Jassim Al Suwaidi
Keywords
Related Articles
- EP ID EP343589
- DOI 10.9734/IJMPCR/2015/20196
- Views 103
- Downloads 0
Samter’s Triad: Rare or Under-Diagnosed?
Samter’s triad is an acquired inflammatory disorder characterized by asthma, nasal polyps and aspirin sensitivity. Aspirin sensitivity is the hallmark of this condition. It is a form of pseudo-allergy, as IgE does not pl...
Giant Cell Fibroma: A Case Report Concerning an Unusual Lesion of the Oral Cavity
Aims: We describe the case of a young man with giant cell fibroma (GCF) of the oral cavity. Cases such as this are rare and we believe that our research adds to the literature concerning this area of study. Presentation...
Skin as a Site of Recurrence in Carcinoma Ovary- An Unusual Presentation
Cutaneous metastases from various malignancies have been reported in literature but skin as a site of recurrence in cancer ovary has been seldom reported. We hereby report one such case of a 47 year old, follow up case o...
An Uncommon Case of Phenibut Toxicity in an Intensive Care Unit
Gamma-aminobutyric acid (GABA) agonists are used as exogenous neuromodulators for patients with chronic pain and refractory mental illness. Phenibut is a controlled GABA-B agonist, with an extensive use in Russia for psy...
Detection of Metastatic Lung Cancer by Immunocytochemistry and Flow Cytometry in a Sample of Pleural Fluid
Malignant pleural effusions (MPE) are common complications in cancer patients and indicate the spread of the primary disease (metastasis). For over a century, malignant effusion has been diagnosed through the observation...