VISUAL FIELD DEFECTS IN PATIENTS OF TUBERCULOSIS ON ETHAMBUTOL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 23
Abstract
BACKGROUND Ethambutol causes retrobulbar neuritis that is related to the dose and duration of treatment, hence we undertook a prospective study of optic nerve function in patients on ethambutol. MATERIALS AND METHODS This study was conducted with a sample size of 100 patients. Patients diagnosed who were having tuberculosis and to be started on ethambutol along with other ATT drugs according to RNTCP regimen underwent detailed relevant history, examination and investigation. The best corrected Visual Acuity (VA), Colour Vision (CV) with Ishihara and visual field examination with Interzeag Octopus 1-2-3 automated perimeter were recorded and repeated every month. Mean Cumulative Dose (MCD) of ethambutol was calculated for each patient and statistical significance was done using Chi-square and paired t-test. RESULTS Out of 160 eyes (20 lost for follow up), 10 (6.25%) eyes developed Visual Field Defects (VFD) and abnormal VA was present in 10 (6.25%) eyes. MCD of patients with abnormal VA was more than MCD of patients with normal VA, but the difference was not statistically significant. CV abnormalities were present in 6 (3.7%) had strong association with VFD (p<0.00001) was dose dependent (p<0.001). CONCLUSION The study has demonstrated that visual field testing by automated perimetry is more sensitive and specific for detecting early ocular toxicity of ethambutol as compared to VA testing. The toxic effect of ethambutol on the eye can’t be predicted on an individual basis, there is a need for a complete ocular evaluation of every patient on ethambutol.
Authors and Affiliations
Roopa Bharamshetter S
Keywords
Related Articles
- EP ID EP215283
- DOI 10.18410/jebmh/2017/258
- Views 88
- Downloads 0
OBLITERATION OF COSTOPHRENIC ANGTE IN A PLAIN X-RAY CHEST
Obliteration of Costophrenicangle can be a pleural effusion in a majority of cases but other causes of mediastinal masses, aortic aneurysm, postpneumonectomy, lung and pleural masses and consolidation and collapse of the...
A STUDY ON ASSOCIATION OF DEPRESSION WITH SOCIAL SUPPORT AND QUALITY OF LIFE AMONG WOMEN LIVING WITH HIV/AIDS IN SOUTH INDIA
BACKGROUND Women bear the brunt of disastrous effects of HIV/AIDS as they are the major caregivers and in return they get very less support and care. Depression is the commonest psychiatric condition seen in HIV positive...
RARE BRANCHIAL ARCH ANOMALIES
AIM Amongst the branchial arch anomalies third arch anomaly occurs rarely and more so the fourth arch anomalies. We present our experience with cases of rare branchial arch anomalies. PATIENTS AND METHODS From June 2006...
HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION AFTER INTRAVENOUS DEXMEDETOMIDINE: A COMPARISON BETWEEN TWO DOSES
BACKGROUND Many pharmacological drugs are used to attenuate the haemodynamic response to laryngoscopy and endotracheal intubation. Dexmedetomidine, a highly selective α2 agonist has pharmacological properties like sedati...
COMPARISON OF 0.1% ADAPALENE CREAM WITH 0.1% TAZAROTENE CREAM IN THE TREATMENT OF ACNE VULGARIS
BACKGROUND Acne vulgaris is a self-limiting disorder of the pilosebaceous unit that is seen primarily in adolescents. Acne therapy aims at reduction of sebum production, correcting the abnormal ductal keratinisation, red...