Wartość oznaczeń wybranych parametrów diagnostycznych: ferrytyny, ultraczułego CRP i rozpuszczalnych fragmentów cytokeratyny 18. (TPS) w ocenie skuteczności terapii chorych z polipami nosa
Journal Title: Otolaryngologia Polska - Year 2014, Vol 68, Issue 1
Abstract
Background: Chronic rhinosinusitis with nasal polyps is social, clinical and cost-effective problem, by reason of bothersome symptoms, chronic nature of the disease, tendency to recur and lack of satisfying treatment. Aim: The aim of this study is assessment of suitability of hsCRP, ferritin and blood levels in nasal polyps patients in evaluation of treatment efficacy. Methods: The study enrolled 38 patients between 20 and 68 years of age. Patients were divided into 2 groups. Levels of ultrasensitive CRP ferritin and TPS have been measured in all patients. The ultrasensitive CRP levels have been measured by chemiluminescence method. Ferritin levels have been measured by MEIA method. The TPS levels have been measured by chemiluminescence method. Results: Comparison of mean ferritin levels in both study groups in each stage of observation shows the significant difference of mean values in only 6 weeks after surgery. Mean ferritin level is significantly lower in group I than in group II (p < 0.05). Mean hsCRP levels vary from one correspon- ding to ferritin levels. Statistically significant difference between study groups in 2nd and 6th week after surgery has been ascertained (p < 0.05). Similarly, like in ferritin levels, the TPS levels are significantly different in 6th week after surgery. Conclusions: Analysis of ferritin, hsCRP and TPS serum levels indicates that these may be useful in assessment of treatment efficacy in patients with nasal polyps. Rise of the chosen inflammatory state parameter level in the postoperative monitoring and anti-inflammatory treatment introduction in nasal polyps patients may inhibit the recurrence of the disease.
Authors and Affiliations
Jacek Pałac, Szczepan Bratek, Robert Partyka, Maciej Misiołek
Keywords
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