What does the Data of 354,725 Patients from Turkey Tell Us About Cervical Smear Epithelial Cell Abnormalities? - The Epithelial Cell Abnormality Rate is Increasing - Quality Control Studies and Corrective Activity are Musts
Journal Title: Turkish Journal of Pathology - Year 2017, Vol 33, Issue 2
Abstract
Objective: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. Material and Method: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities. The study was designed to cover the cervical cytology results during 2013. The results were evaluated from the data based on an online questionnaire. Results: The total number of Epithelial Cell Abnormality was 18,020 and the global Epithelial Cell Abnormality rate was 5.08% in the total 354,725 smears and ranging between 0.3% to 16.64% among centers. The Atypical squamous cells /Squamous intraepithelial lesion ratios changed within the range of 0.21-13.94 with an average of 2.61. When the centers were asked whether they performed quality assurance studies, only 14 out of 28 centers, which shared the information, had such a control study and some quality parameters were better in these centers. Conclusion: There is an increase in the global Epithelial Cell Abnormality rate and there are great differences among centers. Quality control studies including the Atypical squamous cells/Squamous intraepithelial lesion ratio are important. Corrective and preventive action according to quality control parameters is a must. A cervical cytology subspecialist in every center can be utopic but a dedicated pathologist in the center is certainly needed.
Authors and Affiliations
İlknur ÇETİNASLAN TÜRKMEN, Alp USUBÜTÜN, Aslı ÇAKIR, Özlem AYDIN, Filiz AKA BOLAT, Metin AKBULUT, Serdar ALTINAY, Sema ARICI, Figen ASLAN, Müzeyyen ASTARCI, Emine KILIÇ BAĞIR, Yılmaz BAŞ, Nuray BAŞSÜLLÜ, Betül ÇELİK, Handan ÇETİNER, Bengü ÇOBANOĞLU, Abdullah AYDIN, Hale DEMİR, Hayriye TATLI DOĞAN, Kamile Gülçin EKEN, Selma ŞENGİZ ERHAN, Gülgün ERDOĞAN, Kıvılcım EREN ERDOĞAN, Funda EREN, Şafak ERSÖZ, Pınar FIRAT, İclal GÜRSES, Nihan HABERAL, Dudu SOLAKOĞLU KAHRAMAN, Gülçin HARMAN KAMALI, Yasemin YUYUCU KARABULUT, Mehmet KEFELİ, Meral KOYUNCUOĞLU, R. Doğan KÖSEOĞLU, Bahar MÜEZZİNOĞLU, Binnur ONAL, Sevgen ÖNDER, Zuhal ÖZCAN, Elife KIMILOĞLU, Hatice ÖZER, F. Cavide SÖNMEZ, Sevinç ŞAHİN, Nurhan ŞAHİN, Tülin YALTA
Keywords
Related Articles
- EP ID EP255263
- DOI 10.5146/tjpath.2016.01380
- Views 62
- Downloads 0
Are CD68 and Factor VIII-RA Expression Different in Central and Peripheral Giant Cell Granuloma of Jaw: An Immunohistochemical Comparative Study
Objective: Central giant cell granuloma and peripheral giant cell granuloma of the jaw and oral cavity are identical in histopathologic features, although they are different in pathogenesis and clinical behavior. The aim...
An Unusual Case of Thyroid Papillary Carcinoma with Solitary Cerebral Metastasis Presenting with Neurological Symptoms.
Papillary carcinoma of the thyroid is well known for metastasis to regional lymph nodes resulting in early detection and overall favorable prognosis. Solitary metastasis of papillary carcinoma of the thyroid in the cereb...
The Role of EGFR, Hepatocyte Growth Factor Receptor (c-Met), c-ErbB2 (HER2-neu) and Clinicopathological Parameters in the Pathogenesis and Prognosis of Chordoma
Objective: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recu...
Subcutaneous Leiomyosarcoma Metastasized to the Lymph Nodes Involved with Small Lymphocytic Lymphoma / Chronic Lymphocytic Leukemia
Herein, we present a case of a 76-year-old Caucasian man with a very large fungating, ulcerating mass, involving the right neck and parotid area, which developed while he was being treated for chronic lymphocytic leukemi...
The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2017 (4th) Edition
The 4th edition of the World Health Organization (WHO) Classification of Head and Neck Tumors was published in January 2017. The edition serves to provide an updated classification scheme, and extended genetic and molecu...