Widespread and Fungating Kaposi Sarcoma in an HIV Negative Patient
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 9
Abstract
Abstract: Kaposi sarcoma (KS) is a vascular neoplasm of the endothelial cells that commonly occurs in conditions that may lead to severe immunosuppression, e.g. HIV/AIDS, malignancies or use of immune suppressing medications.The development of KS has been linked to infection with an oncogenic virus, the Human Herpes Virus 8 (HHV-8), also known as KS-associated herpes virus (KSHV). Rarely KS also occurs in individuals with no clinical or pathological evidence of immunosuppression as described in the elderly male population of Mediterranean origin, the Ashkenazi Jews and younger population in parts of Central Africa where the oncogenic virus is endemic.Lesions in non AIDS KS are usually localized and typically involve the lower limbs. Widespread and generalized KS occur more in individuals suffering from HIV/AIDS. We describe a case of a HIV negative 51year old Nigerian male who presented with generalized cutaneous KS. Diagnosis was made by a combination of clinical description, imaging studies and histopathology.Clinical presentation of KS ranges from mild (localized cutaneous) to severe (generalized cutaneous and visceral) features. Treatment modalities are available for KS and use of any particular type of treatment depends largely on the distribution of lesions, visceral organ involvement and the presence or absence of immunosuppression. Treatment of KS, particularly cutaneous presentations does not restore the skin to its premorbid state however early diagnosis and treatment is necessary to achieve a significantly improved outcome. Keywords: Kaposi sarcoma, Human Herpes Virus 8, AIDS, HIV, KS-associated herpes virus (KSHV), Neoplasm
Authors and Affiliations
BU Okwara, AN Onunu, A Adeyekun, E Ogunbor
Keywords
Related Articles
- EP ID EP388438
- DOI -
- Views 141
- Downloads 0
On the Pharmacists’ Attitudes toward the Off Label Use of Cosmeceutical Products in Taiwan
Abstract: To assure the quality, safety and efficacy of a drug, a drug will be developed, tested, delivered, and used under strict regulatory legislations. Off-label prescribing refers to prescribing or use a registered...
Assessment of zinc, Lipid profile and HB A1c in Sudanese with Type II Diabetes Mellitus in Khartoum State
Abstract: Type 2 diabetes mellitus is associated with increased metabolic processes and oxidative stress. The trace elements are important co-factors in these events. Thus this study was conducted to compare serum levels...
Serum Ghrelin and Adiponectin Level With Insulin Resistance Parameters in Obese Patients with Polycystic Ovary Syndrome Treated By Metformin
To evaluate the effect of metformin therapy for more than three months on serum ghrelin and adiponectin level and to assess the relationship between them with insulin resistance parameters in obese patients with polycyst...
Prescription Pattern of Anti-Obesity Drug Among the Patients of Obesity: A Prospective Study
Despite the availability of efficacious anti-obesity drugs (AOD), very few doctors are prescribing them to the patients. To assess the anti-obesity drug (AOD) prescription pattern in obese patients. Ninety four obese pat...
Fib-04 Score at the End of Treatment in Chronic Hepatitis C Patients Treated with Pegylated Interferon and Ribavirin: An Observational Study
Abstract: FIB-4 Score is a simple formula to predict liver fibrosis based on the standard biochemical / hematological values i.e. AST, ALT, Platelet count and age. The Score lower than 1.45 has a Negative Predictive Valu...