WILMS TUMOUR WITH RHABDOID DIFFERENTIATION
Journal Title: INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY - Year 2017, Vol 1, Issue 4
Abstract
Wilms tumour is most common pediatric renal neoplasm having a peak incidence between 2-5 years of age. The classic Wilms tumour contain blastemal, epithelial and stromal component. It may differentiate into more mature mesenchymal tissue type such as skeletal muscle following chemotherapy. We present a case of 5 year female presented with history of abdominal mass for 6 month and haematuria for 2 months. CECT reveals a mass of size (13.4 x 9.8) cm2 in abdominopelvic cavity with necrotic area. Radical nephrectomy was done following neoadjuvant chemotherapy. The histopathological examination of tumour specimen showed admixture of blastemal, tubular and mesenchymal component with extensive rhabdoid differentiation. Capsular invasion not seen. Immunohistochemisry showed positive for desmin. Chemotherapy is extremely effective in Wilms tumour but rhabdomyoblastic stromal components are more chemoresistant than the other component.
Authors and Affiliations
Dr. Muktanjalee Deka, Dr. Gabyanjali Devi
Keywords
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WILMS TUMOUR WITH RHABDOID DIFFERENTIATION
Wilms tumour is most common pediatric renal neoplasm having a peak incidence between 2-5 years of age. The classic Wilms tumour contain blastemal, epithelial and stromal component. It may differentiate into more mature m...