WOUND HEALING ACTIVITY OF AQUEOUS EXTRACTS OF FICUS RELIGIOSA AND FICUS BENGHALENSIS LEAVES IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 2
Abstract
Ficus is an evergreen tree of family Moraceae with more than 800 species. It has been traditionally claimed that the whole plant (especially leaves) of Ficus religiosa and Ficus benghalensis are useful in wound healing. Moreover, the leaves of the plant are reported to have anti-inflammatory, antioxidant, and antimicrobial properties. In the present study, wound healing activity of aqueous extracts of Ficus religiosa and Ficus benghalensis was evaluated in rats using excision, incision and dead space model along with estimation of biochemical parameters. In the incision and excision wound model, the breaking strength and percent wound contraction or closure was evaluated respectively. While in the dead space model, the efficacy of drugs against the proliferative and remodeling phases of wound healing was evaluated. In addition, GSH, Catalase and MDA estimation studies were employed to assess the efficacy of both the plants in vivo. The treatment of wound with ointment containing aqueous extracts of Ficus religiosa and Ficus benghalensis exhibited significant wound healing. The results were comparable to standard drug povidone iodine ointment, in terms of wound contraction, tensile strength and histopathological parameters. A significant antioxidant activity was observed as evidenced from decreased level of MDA and increased the level of GSH, catalase in extract treated animals as compared to control animals.
Authors and Affiliations
Nidhi Chowdhary, Mohanjit Kaur, Amarjeet Singh, Bimlesh Kumar
Keywords
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