Zinc-induced adaptive changes in NMDA/glutamatergic and serotonergic receptors.
Journal Title: Pharmacological Reports - Year 2009, Vol 61, Issue 6
Abstract
Preclinical data indicate the involvement of glutamatergic and serotonergic pathways in the antidepressant activity of zinc. The present study investigated alterations in N-methyl-D-aspartate (NMDA)/glutamatergic and serotonergic receptors (using radioligand binding) induced by chronic treatment (14-day) with zinc hydroaspartate (65 mg/kg). Moreover, the mRNA and protein levels of brain-derived neurotrophic factor (BDNF) were also assessed. Chronic zinc administration reduced the affinity of glycine to glycine/NMDA receptors in the rat frontal cortex and increased the density of 5-HT(1A) and 5-HT(2A) serotonin receptors in the hippocampus and frontal cortex, respectively. These receptor alterations may be in part due to increased BDNF mRNA and protein levels in the rat frontal cortex. These results indicate that chronic zinc treatment alters glutamatergic and serotonergic systems, which is a hallmark of clinically effective antidepressants.
Authors and Affiliations
Agnieszka Cichy, Magdalena Sowa-Kućma, Beata Legutko, Lucyna Pomierny-Chamioło, Agata Siwek, Anna Piotrowska, Bernadeta Szewczyk, Ewa Poleszak, Andrzej Pilc, Gabriel Nowak
Keywords
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