ЗНАЧЕННЯ МІТОХОНДРІАЛЬНОЇ ДИСФУНКЦІЇ У РОЗВИТКУ НЕАЛКОГОЛЬНОГО СТЕАТОГЕПАТИТУ
Journal Title: Science Review - Year 2018, Vol 3, Issue 1
Abstract
Objective: Improvement of the diagnosis of non-alcoholic steatohepatitis (NASH) and the development of optimally effective methods for correcting the revealed violations. Materials and Methods: examined 65 patients with verified NASH. The age of the patients ranged from 23 to 67 years. Among them were 36 (55.4 %) women and 29 (44.6 %) men. The control group consisted of 20 healthy individuals. The effectiveness of complex therapy with the inclusion of the drug L-carnitine, deproteinized hemoderivat of calves and folic acid was studied. Results: The presence of carnitine insufficiency, hyperhomocysteinemia, increase in the level of proinflammatory cytokines in all patients with NASH. After a month of treatment with complex therapy, the level of L-carnitine increased from 14.5 (13.1, 15.7) μmol/l to 31.1 (28.8, 34.1) μmol/l (p<0.001), homocysteine decreased to subnormal figures - 11.8 (11.0, 12.8) μmol/l (p<0.001). When studying the cytokine profile in the group after treatment, a significant decrease in the level of proinflammatory cytokines was revealed. Conclusion: The use of complex therapy with the inclusion of drugs L-carnitine, deproteinized hemoderevate blood of calves as an antihypoxant and folic acid has a positive effect on the clinical course of the disease, contributes to the elimination of L-carnitine deficiency, hyperhomocysteinemia, a decrease in the level of pro-inflammatory cytokines.
Authors and Affiliations
Т. Д. Звягінцева, С. В. Глущенко
Keywords
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